Evidence map›Paper›PMID 36188756›Full record

ArticleInternational journal of cardiology. Heart & vasculature2022

Atrial fibrillation is a risk factor for major adverse cardiovascular events in COVID-19.

Michael J Cutler, Heidi T May, Tami L Bair, Brian G Crandall, Jeffrey S Osborn, Jared D Miller, Charles D Mallender, Joseph B Muhlestein, Jeffrey L Anderson, Kirk U Knowlton and 1 more

Abstract read
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Recent highlights from theInternational journal of cardiology. Heart & vasculature · 2023
    Article
  5. Review
  6. Article
  7. COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Impact of New Onset Atrial Fibrillation in Hospitalized Patients with COVID-19. Results of the "ACO-VID" Registry.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael J CutlerIntermountain Medical Center, Intermountain Heart Institute, Murray, UT, United States.
Heidi T MayIntermountain Medical Center, Intermountain Heart Institute, Murray, UT, United States.
Tami L BairIntermountain Medical Center, Intermountain Heart Institute, Murray, UT, United States.
Brian G CrandallIntermountain Medical Center, Intermountain Heart Institute, Murray, UT, United States.
Jeffrey S OsbornIntermountain Medical Center, Intermountain Heart Institute, Murray, UT, United States.
Jared D MillerIntermountain Medical Center, Intermountain Heart Institute, Murray, UT, United States.
Charles D MallenderIntermountain Medical Center, Intermountain Heart Institute, Murray, UT, United States.
Joseph B MuhlesteinIntermountain Medical Center, Intermountain Heart Institute, Murray, UT, United States.
Jeffrey L AndersonIntermountain Medical Center, Intermountain Heart Institute, Murray, UT, United States.
Kirk U KnowltonIntermountain Medical Center, Intermountain Heart Institute, Murray, UT, United States.
Stacey KnightIntermountain Medical Center, Intermountain Heart Institute, Murray, UT, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: New-onset atrial fibrillation (AF) during COVID-19 infection is associated with worse cardiovascular outcomes and mortality, with new-onset AF being associated with worse clinical outcomes than recurrent AF. However, it is not known whether a prior history of AF is an independent cardiovascular risk factor predicting worse outcomes in COVID-19 patients. The present investigation sought to determine whether AF should be considered a risk factor for worse outcomes in COVID-19 illness. Methods: From March 2020-September 2021 patients testing positive for SARS-CoV-2 with a prior AF diagnosis (n = 3623) were propensity matched to non-AF SARS-CoV-2 positive patients (n = 3610). Multivariable Cox hazard regression was used to determine subsequent MACE (all-cause death, myocardial infarction, HF and stroke) risk among patients with and without AF. Results: COVID-19 patients with a prior history of AF were more likely to be hospitalized, require ICU care, supplemental oxygen, and ventilator support compared COVID-19 patients without a history of AF. There was a 1.40 times higher rate of MACE in the COVID-19 patients with prior AF compared to patients without prior AF ( Conclusion: AF history was shown to be an independent risk factor for MACE during a COVID-19 illness. Both recurrent and principally new-onset AF were associated with an increased risk of poor clinical outcomes during COVID-19 illness.

Indexed as

Atrial fibrillationCOVID-19Major adverse cardiovascular events

Identifiers

PMID36188756
PMCPMC9513337

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.