Evidence map›Paper›PMID 36188475›Full record

ArticleFrontiers in neuroscience2022

Apolipoprotein E knockout may affect cognitive function in D-galactose-induced aging mice through the gut microbiota-brain axis.

Bowei Chen, Jian Yi, Yaqian Xu, Huiqiao Wen, Fengming Tian, Yingfei Liu, Lan Xiao, Lisong Li, Baiyan Liu

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bowei ChenThe First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
Jian YiThe First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
Yaqian XuThe First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
Huiqiao WenThe First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
Fengming TianThe First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
Yingfei LiuThe First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
Lan XiaoCollege of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
Lisong LiCollege of Information Science and Engineering, Hunan University of Chinese Medicine, Changsha, China.
Baiyan LiuHunan Academy of Chinese Medicine, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota plays an important role in central nervous system (CNS) disorders. Apolipoprotein E (ApoE) can affect the composition of the gut microbiota and is closely related to the CNS. However, the mechanism by which ApoE affects cognitive dysfunction through the gut microbiota-brain axis has thus far not been investigated. In this study, we used wild-type mice and ApoE knockout (ApoE

Indexed as

agingapolipoprotein Ecognitive functiongut microbiotametabolomicsoxidative stress

Identifiers

PMID36188475
PMCPMC9520596

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.