Evidence map›Paper›PMID 36188450›Full record

ArticleFrontiers in neuroscience2022

Maternal sensitivity at the age of 8 months associates with local connectivity of the medial prefrontal cortex in children at 5 years of age.

Anni Copeland, Riikka Korja, Saara Nolvi, Olli Rajasilta, Elmo P Pulli, Venla Kumpulainen, Eero Silver, Ekaterina Saukko, Hetti Hakanen, Eeva Holmberg and 7 more

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Pre- and postnatal maternal depressive symptoms associated with local connectivity of the left amygdala in 5-year-olds.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anni CopelandFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Riikka KorjaFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Saara NolviFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Olli RajasiltaFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Elmo P PulliFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Venla KumpulainenFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Eero SilverFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Ekaterina SaukkoDepartment of Radiology, Turku University Hospital, Turku, Finland.
Hetti HakanenFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Eeva HolmbergFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Eeva-Leena KatajaFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Suvi HäkkinenFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Riitta ParkkolaDepartment of Radiology, University of Turku and Turku University Hospital, Turku, Finland.
Tuire LähdesmäkiDepartment of Pediatric Neurology, Turku University Hospital and University of Turku, Turku, Finland.
Linnea KarlssonFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Hasse KarlssonFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
Jetro J TuulariFinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The quality of mother-child interaction, especially maternal sensitivity in caregiving behavior, plays an important role in a child's later socioemotional development. Numerous studies have indicated associations between poor mother-child interaction and offspring brain structure and function, but more knowledge on how variation in the characteristics of early caregiving is associated with children's brain structure and function is needed. We investigated whether maternal sensitivity at 8 or 30 months is associated with functional connectivity in a child's brain at 5 years of age based on the FinnBrain Birth Cohort Study (17 and 39 mother-child dyads at 8 and 30 months, respectively, with an overlap of 13 dyads). Maternal sensitivity was assessed during a free play interaction using the Emotional Availability Scales at 8 and 30 months of the children's age. Task-free functional magnetic resonance imaging (fMRI) was acquired at the age of 5 years in 7-min scans while watching the

Indexed as

functional connectivityfunctional magnetic resonance imagingmaternal caregiving behaviormaternal sensitivitymedial prefrontal cortexparent-child interaction

Identifiers

PMID36188450
PMCPMC9520291

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.