Evidence map›Paper›PMID 36188347›Full record

ArticleACS central science2022

Label-Free Single-Molecule Pulldown for the Detection of Released Cellular Protein Complexes.

Guangzhong Ma, Pengfei Zhang, Xinyu Zhou, Zijian Wan, Shaopeng Wang

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Label-Free Single-Molecule Immunoassay.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Guangzhong MaBiodesign Center for Biosensors and Bioelectronics, Arizona State University, Tempe, Arizona 85287, United States.ORCID https://orcid.org/0000-0002-1197-659X
Pengfei ZhangBiodesign Center for Biosensors and Bioelectronics, Arizona State University, Tempe, Arizona 85287, United States.ORCID https://orcid.org/0000-0002-3595-0490
Xinyu ZhouBiodesign Center for Biosensors and Bioelectronics, Arizona State University, Tempe, Arizona 85287, United States.ORCID https://orcid.org/0000-0003-1399-828X
Zijian WanBiodesign Center for Biosensors and Bioelectronics, Arizona State University, Tempe, Arizona 85287, United States.ORCID https://orcid.org/0000-0001-7923-6451
Shaopeng WangBiodesign Center for Biosensors and Bioelectronics, Arizona State University, Tempe, Arizona 85287, United States.ORCID https://orcid.org/0000-0002-2680-0503
BioElectronics (United States) · US

Funding

Quantitative label-free imaging of membrane protein interaction kinetics on cellsR01GM107165 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WANG, SHAOPENG · 2014 to 2021
$2.2M
Optical imaging of size, charge, mobility and binding of single proteinsR01GM140193 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WANG, SHAOPENG · 2022 to 2025
$1.2M
NIGMS NIH HHS R01 GM107165NIGMS NIH HHS R01 GM140193
6 · The paper itself

Abstract

Precise and sensitive detection of intracellular proteins and complexes is key to the understanding of signaling pathways and cell functions. Here, we present a label-free single-molecule pulldown (LFSMP) technique for the imaging of released cellular protein and protein complexes with single-molecule sensitivity and low sample consumption down to a few cells per mm

Identifiers

PMID36188347
PMCPMC9523780
OpenAlexW4293805251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.