Evidence map›Paper›PMID 36188342›Full record

ArticleACS central science2022

Potent Virustatic Polymer-Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo.

Adrian Najer, Joshua Blight, Catherine B Ducker, Matteo Gasbarri, Jonathan C Brown, Junyi Che, Håkon Høgset, Catherine Saunders, Miina Ojansivu, Zixuan Lu and 17 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 4 institutions in 3 countries.

Adrian NajerDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.ORCID https://orcid.org/0000-0003-4868-9364
Joshua BlightDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, U.K.
Catherine B DuckerDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, U.K.
Matteo GasbarriInstitute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-8469-5369
Jonathan C BrownDepartment of Infectious Disease, Imperial College London, London, W2 1PG, U.K.ORCID https://orcid.org/0000-0001-6849-3962
Junyi CheDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.
Håkon HøgsetDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.
Catherine SaundersDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.
Miina OjansivuDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Zixuan LuDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.
Yiyang LinDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.ORCID https://orcid.org/0000-0001-8572-649X
Jonathan YeowDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.ORCID https://orcid.org/0000-0003-3709-5149
Omar Rifaie-GrahamDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.
Michael PotterDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.ORCID https://orcid.org/0000-0003-4688-6874
Renée TonkinDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.
Jelle PendersDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.ORCID https://orcid.org/0000-0002-5232-917X
James J DoutchRutherford Appleton Laboratory, ISIS Neutron and Muon Source, STFC, Didcot OX11 ODE, U.K.ORCID https://orcid.org/0000-0003-0747-8368
Athina GeorgiadouDepartment of Infectious Disease, Imperial College London, London, W2 1PG, U.K.
Hanna M G BarrigaDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0002-2530-5332
Margaret N HolmeDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0002-7314-9493
Aubrey J CunningtonDepartment of Infectious Disease, Imperial College London, London, W2 1PG, U.K.
Laurence BugeonDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, U.K.
Margaret J DallmanDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, U.K.
Wendy S BarclayDepartment of Infectious Disease, Imperial College London, London, W2 1PG, U.K.
Francesco StellacciInstitute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-4635-6080
Jake BaumDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, U.K.
Molly M StevensDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, U.K.ORCID https://orcid.org/0000-0002-7335-266X
Imperial College London · GBKarolinska Institutet · SEÉcole Polytechnique Fédérale de Lausanne · CHRutherford Appleton Laboratory · GB

Funding

Medical Research Council MR/W005611/1Wellcome Trust 209121/Z/17/Z
6 · The paper itself

Abstract

Infectious diseases continue to pose a substantial burden on global populations, requiring innovative broad-spectrum prophylactic and treatment alternatives. Here, we have designed modular synthetic polymer nanoparticles that mimic functional components of host cell membranes, yielding multivalent nanomimics that act by directly binding to varied pathogens. Nanomimic blood circulation time was prolonged by reformulating polymer-lipid hybrids. Femtomolar concentrations of the polymer nanomimics were sufficient to inhibit herpes simplex virus type 2 (HSV-2) entry into epithelial cells, while higher doses were needed against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given their observed virustatic mode of action, the nanomimics were also tested with malaria parasite blood-stage merozoites, which lose their invasive capacity after a few minutes. Efficient inhibition of merozoite invasion of red blood cells was demonstrated both

Identifiers

PMID36188342
PMCPMC9092191
OpenAlexW4225415733

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.