Evidence map›Paper›PMID 36188221›Full record

ArticleFrontiers in molecular biosciences2022

Selection of RNA aptamers targeting hypoxia in cancer.

Silvia Nuzzo, Margherita Iaboni, Maria Luigia Ibba, Anna Rienzo, Domenica Musumeci, Monica Franzese, Giuseppina Roscigno, Alessandra Affinito, Gianluca Petrillo, Cristina Quintavalle and 3 more

Abstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Dynamic reprogramming of the tumor immune network via multicycle checkpoint degradation for cancer immunotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Silvia NuzzoIRCCS SYNLAB SDN, Naples, Italy.
Margherita IaboniBracco Imaging S.p.A., Turin, Italy.
Maria Luigia IbbaInstitute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOS), National Research Council (CNR), Naples, Italy.
Anna RienzoInstitute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOS), National Research Council (CNR), Naples, Italy.
Domenica MusumeciDepartment of Chemical Sciences, "Federico II" University of Naples, Naples, Italy.
Monica FranzeseIRCCS SYNLAB SDN, Naples, Italy.
Giuseppina RoscignoDepartment of Molecular Medicine and Medical Biotechnology, "Federico II" University of Naples, Naples, Italy.
Alessandra AffinitoDepartment of Molecular Medicine and Medical Biotechnology, "Federico II" University of Naples, Naples, Italy.
Gianluca PetrilloDepartment of Molecular Medicine and Medical Biotechnology, "Federico II" University of Naples, Naples, Italy.
Cristina QuintavalleInstitute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOS), National Research Council (CNR), Naples, Italy.
Giuseppe CicconeInstitute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOS), National Research Council (CNR), Naples, Italy.
Carla Lucia EspositoInstitute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOS), National Research Council (CNR), Naples, Italy.
Silvia CatuognoInstitute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOS), National Research Council (CNR), Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia plays a crucial role in tumorigenesis and drug resistance, and it is recognised as a major factor affecting patient clinical outcome. Therefore, the detection of hypoxic areas within the tumour micro-environment represents a useful way to monitor tumour growth and patients' responses to treatments, properly guiding the choice of the most suitable therapy. To date, non-invasive hypoxia imaging probes have been identified, but their applicability

Indexed as

aptamercancercell-SELEXdetectionhypoxia

Identifiers

PMID36188221
PMCPMC9515380

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.