Evidence map›Paper›PMID 36188211›Full record

ArticleFrontiers in ophthalmology2022

Bidirectional Effect of IFN-γ on Th17 Responses in Experimental Autoimmune Uveitis.

Hui Shao, Henry J Kaplan, Deming Sun

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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  10. Association of theGenes · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Hui ShaoDepartment of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY, United States.
Henry J KaplanDepartment of Ophthalmology, Saint Louis University School of Medicine, Saint Louis, MO, United States.
Deming SunDoheny Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States.
Saint Louis University · USUniversity of California, Los Angeles · USUniversity of Louisville · US

Funding

Role of IL-17+ Autoreactive T Cells in Experimental Autoimmune Uveitis (EAU)R01EY018827 · NEI · DOHENY EYE INSTITUTE · PI SUN, DEMING · 2009 to 2023
$4.8M
Regulation by Gammadelta T Cells of Autoimmune Uveitis (EAU)R01EY022403 · NEI · DOHENY EYE INSTITUTE · PI SUN, DEMING · 2012 to 2015
$1.6M
NEI NIH HHS R01 EY018827NEI NIH HHS R01 EY022403
6 · The paper itself

Abstract

Pro- and ant-inflammatory effects of IFN-γ have been repeatedly found in various immune responses, including cancer and autoimmune diseases. In a previous study we showed that the timing of treatment determines the effect of adenosine-based immunotherapy. In this study we examined the role of IFN-γ in pathogenic Th17 responses in experimental autoimmune uveitis (EAU). We observed that IFN-γ has a bidirectional effect on Th17 responses, when tested both

Indexed as

autoimmunityexperimental autoimmune uveitisgamma delta T cellIFN-gammaTh17

Identifiers

PMID36188211
PMCPMC9521044
OpenAlexW4220824598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.