Evidence map›Paper›PMID 36188190›Full record

ArticleiScience2022

Evidence of premature lymphocyte aging in people with low anti-spike antibody levels after BNT162b2 vaccination.

Yapei Huang, Juliana E Shin, Alexander M Xu, Changfu Yao, Sandy Joung, Min Wu, Ruan Zhang, Bongha Shin, Joslyn Foley, Simeon B Mahov and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Computational Methods for Single-Cell Proteomics.Annual review of biomedical data science · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 2 institutions in 1 country.

Yapei HuangWomen's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Juliana E ShinBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Alexander M XuBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Changfu YaoWomen's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Sandy JoungDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Min WuDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Ruan ZhangComprehensive Transplant Center, Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Bongha ShinComprehensive Transplant Center, Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Joslyn FoleyBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Simeon B MahovBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Matthew E ModesWomen's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Joseph E EbingerDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Matthew DriverDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Jonathan G BraunResearch Division of Immunology in the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Caroline A JefferiesResearch Division of Immunology in the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Tanyalak ParimonWomen's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Chelsea HayesDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Kimia SobhaniDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Akil MerchantBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Sina A GharibComputational Medicine Core at Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA 98109, USA.
Stanley C JordanComprehensive Transplant Center, Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Susan ChengDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Helen S GoodridgeBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Peter ChenWomen's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Cedars-Sinai Medical Center · USUniversity of Washington · US

Funding

Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2U54CA260591 · NCI · CEDARS-SINAI MEDICAL CENTER · PI FIGUEIREDO, JANE C., KARIN, MICHAEL · 2020 to 2024
$9.1M
Syndecan-1 suppression of lung inflammation - Diversity SupplementR01HL159953 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHEN, PETER · 2022 to 2025
$2.7M
Fungal dysbiosis regulation of post-influenza bacterial pneumoniaR01HL155759 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHEN, PETER · 2021 to 2024
$2.4M
Dynactin 4 regulation of lung injuryR01HL137076 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHEN, PETER, SCHROER, TRINA A · 2018 to 2021
$1.9M
Syndecan-1 regulation of lung fibrosisK08HL141590 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI PARIMON, TANYALAK · 2020 to 2024
$854k
NCI NIH HHS U54 CA260591NHLBI NIH HHS K08 HL141590NHLBI NIH HHS R01 HL137076NHLBI NIH HHS R01 HL155759NHLBI NIH HHS R01 HL159953
6 · The paper itself

Abstract

SARS-CoV-2 vaccines have unquestionably blunted the overall impact of the COVID-19 pandemic, but host factors such as age, sex, obesity, and other co-morbidities can affect vaccine efficacy. We identified individuals in a relatively healthy population of healthcare workers (CORALE study cohort) who had unexpectedly low peak anti-spike receptor binding domain (S-RBD) antibody levels after receiving the BNT162b2 vaccine. Compared to matched controls, "low responders" had fewer spike-specific antibody-producing B cells after the second and third/booster doses. Moreover, their spike-specific T cell receptor (TCR) repertoire had less depth and their CD4

Indexed as

Health sciencesImmunologyMicrobiologyTranscriptomics

Identifiers

PMID36188190
PMCPMC9510055
OpenAlexW4297201463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.