Evidence map›Paper›PMID 36188187›Full record

ReviewFrontiers in medical technology2022

High-throughput and automated screening for COVID-19.

Nestor Jonguitud-Borrego, Koray Malcı, Mihir Anand, Erikan Baluku, Calum Webb, Lungang Liang, Carlos Barba-Ostria, Linda P Guaman, Liu Hui, Leonardo Rios-Solis

Abstract readReview
In one paragraph

Review in Frontiers in medical technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Machine-Learning-Aided Advanced Electrochemical Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nestor Jonguitud-BorregoInstitute for Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh, United Kingdom.
Koray MalcıInstitute for Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh, United Kingdom.
Mihir AnandSchool of Biochemical Engineering, Indian Institute of Technology BHU, Varanasi, India.
Erikan BalukuSchool of Bio-Security, Biotechnical and Laboratory Sciences Makerere University, Kampala, Uganda.
Calum WebbInstitute for Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh, United Kingdom.
Lungang LiangBGI Clinical Laboratories, BGI-Shenzhen, Shenzhen, China.
Carlos Barba-OstriaEscuela de Medicina, Colegio de Ciencias de la Salud Quito, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
Linda P GuamanCentro de Investigación Biomédica (CENBIO), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador.
Liu HuiBGI Clinical Laboratories, BGI-Shenzhen, Shenzhen, China.
Leonardo Rios-SolisInstitute for Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has become a global challenge for the healthcare systems of many countries with 6 million people having lost their lives and 530 million more having tested positive for the virus. Robust testing and a comprehensive track and trace process for positive patients are essential for effective pandemic control, leading to high demand for diagnostic testing. In order to comply with demand and increase testing capacity worldwide, automated workflows have come into prominence as they enable high-throughput screening, faster processing, exclusion of human error, repeatability, reproducibility and diagnostic precision. The gold standard for COVID-19 testing so far has been RT-qPCR, however, different SARS-CoV-2 testing methods have been developed to be combined with high throughput testing to improve diagnosis. Case studies in China, Spain and the United Kingdom have been reviewed and automation has been proven to be promising for mass testing. Free and Open Source scientific and medical Hardware (FOSH) plays a vital role in this matter but there are some challenges to be overcome before automation can be fully implemented. This review discusses the importance of automated high-throughput testing, the different equipment available, the bottlenecks of its implementation and key selected case studies that due to their high effectiveness are already in use in hospitals and research centres.

Indexed as

automationCOVID-19diagnostichigh-throughputSARS-coV-2

Identifiers

PMID36188187
PMCPMC9521367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.