Evidence map›Paper›PMID 36188006›Full record

ArticleFrontiers in microbiology2022

Evaluation of phages and liposomes as combination therapy to counteract

Marco Cafora, Noemi Poerio, Francesca Forti, Nicoletta Loberto, Davide Pin, Rosaria Bassi, Massimo Aureli, Federica Briani, Anna Pistocchi, Maurizio Fraziano

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Cystic fibrosis: insights from zebrafish models.Disease models & mechanisms · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Studying Bacteriophage Efficacy Using a Zebrafish Model.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  8. Bacteriophage-mediated approaches for biofilm control.Frontiers in cellular and infection microbiology · 2024
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marco CaforaDipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Segrate, MI, Italy.
Noemi PoerioDipartimento di Biologia, Università degli Studi di Roma "Tor Vergata", Rome, Italy.
Francesca FortiDipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.
Nicoletta LobertoDipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Segrate, MI, Italy.
Davide PinDipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Segrate, MI, Italy.
Rosaria BassiDipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Segrate, MI, Italy.
Massimo AureliDipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Segrate, MI, Italy.
Federica BrianiDipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.
Anna PistocchiDipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Segrate, MI, Italy.
Maurizio FrazianoDipartimento di Biologia, Università degli Studi di Roma "Tor Vergata", Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multi drug resistant (MDR) bacteria are insensitive to the most common antibiotics currently in use. The spread of antibiotic-resistant bacteria, if not contained, will represent the main cause of death for humanity in 2050. The situation is even more worrying when considering patients with chronic bacterial infections, such as those with Cystic Fibrosis (CF). The development of alternative approaches is essential and novel therapies that combine exogenous and host-mediated antimicrobial action are promising. In this work, we demonstrate that asymmetric phosphatidylserine/phosphatidic acid (PS/PA) liposomes administrated both in prophylactic and therapeutic treatments, induced a reduction in the bacterial burden both in wild-type and

Indexed as

bacteriophagescystic fibrosisliposomespseudomonaszebrafish

Identifiers

PMID36188006
PMCPMC9520727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.