ArticleInternational journal of reproductive biomedicine2022
Chronic scrotal heat stress causes testicular interstitial inflammation and fibrosis: An experimental study in mice.
Article in International journal of reproductive biomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Combined effects of thermal stress and benzene or toluene exposure on the immune and reproductive disruption in Nile tilapia (Oreochromis niloticus).Scientific reports · 2026Article
- CanInternational journal of molecular sciences · 2026Article
- Testicular Photohyperthermia Mediated by Magnetic Nanoparticles: Implications for Male Fertility Control.Molecules (Basel, Switzerland) · 2026Article
- Dose-Dependent Effects of Intratesticular Adipose-Derived Mesenchymal Stem Cell Injection on Heat-Induced Spermatogenesis Disorder in Wistar Rats: Focus on Apoptosis and Oxidative Stress.Iranian journal of pathology · 2026Article
- Environmental stress and stallion fertility: mechanistic insights, evidence gaps, and functional implications.Frontiers in veterinary science · 2026Review
- Article
- Resveratrol mitigates heat stress-induced testicular injury in rats: enhancing male fertility via antioxidant, antiapoptotic, pro-proliferative, and anti-inflammatory mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Antioxidant Capacity of Thyme (Thymus vulgaris) Essential Oil and Its Effect on In Vivo Fertility of Rams Subjected to Testicle Heat Stress.Journal of animal physiology and animal nutrition · 2025Article
- A determination of the main regulators of necroptosis in testicular tissue under different heat stresses.Journal of molecular histology · 2025Article
- The Impact of High-Temperature Stress on Gut Microbiota and Reproduction in Siberian Hamsters (Microorganisms · 2024Article
- A Review of the Effects of Some Extrinsic Factors on Mice Used in Research.Comparative medicine · 2023Review
- Risk Factors for Testicular Cancer: Environment, Genes and Infections-Is It All?Medicina (Kaunas, Lithuania) · 2023Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic heat stress is a risk factor that adversely affects the reproduction system. Inflammation and fibrosis are 2 important response processes to damaged tissues. Objective: This study investigates the association of chronic scrotal heat stress with testicular interstitial inflammation and fibrosis in mice. Materials and Methods: For all experiments, 8-10 wk old male Swiss mice ( Results: Chronic scrotal heat stress impairs spermatogenesis and reverses testicular histological structure. In this study, heat stress significantly induced increased interstitial cell proliferation and upregulation of intercellular adhesion molecule-1 expression in the interstitial testicular tissue. In the interstitial testicular tissue, the number of F4/80-positive macrophages and the number of fibroblast-specific protein 1-positive fibroblasts were significantly increased in the heat-exposed groups compared to those in the control group. The heat exposed groups had substantially increased extracellular matrix collagen accumulation in their testicular interstitial tissues. Conclusion: Heat stress adversely affects the testicular structure and spermatogenesis, causes inflammation, and leads to testicular interstitial fibrosis.
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