Evidence map›Paper›PMID 36187725›Full record

ArticleNeurology. Genetics2022

Efficacy, Tolerability, and Retention of Antiseizure Medications in

Jan H Döring, Afshin Saffari, Thomas Bast, Knut Brockmann, Laura Ehrhardt, Walid Fazeli, Wibke G Janzarik, Annick Klabunde-Cherwon, Gerhard Kluger, Hiltrud Muhle and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Complexity in Genetic Epilepsies: A Comprehensive Review.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jan H DöringDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Afshin SaffariDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-4119-7519
Thomas BastDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Knut BrockmannDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Laura EhrhardtDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Walid FazeliDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Wibke G JanzarikDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Annick Klabunde-CherwonDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Gerhard KlugerDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Hiltrud MuhleDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Manuela PendziwiatDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-8942-8334
Rikke S MøllerDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-9664-1448
Konrad PlatzerDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-6127-6308
Joana Larupa SantosDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Julian SchröterDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Georg F HoffmannDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Stefan KölkerDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.
Steffen SyrbeDivision of Paediatric Epileptology (J.H.D., A.K.-C., J.S., S.S.), Centre for Paediatric and Adolescent Medicine, University Hospital Heidelberg; Division of Paediatric Neurology and Metabolic Medicine (A.S., G.F.H., S.K.), Centre for Paediatric and Adolescent Medicine, University Hospital; Epilepsy Center Kork (T.B.), Kehl-Kork; Medical Faculty (T.B.), University of Freiburg, Freiburg im Breisgau; Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders (K.B.), Children's Hospital, University Medical Center, Göttingen; Department of Pediatrics (L.E.), University Medicine Mainz; Pediatric Neurology (W.F.), Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne; Institute for Molecular and Behavioral Neuroscience (W.F.), Faculty of Medicine and University Hospital Cologne, University of Cologne; Department of Neuropediatrics and Muscle Disorders (W.G.J.), Faculty of Medicine, University of Freiburg; Clinic for Neuropediatrics and Neurorehabilitation (G.K.), Epilepsy Center for Children and Adolescents, Schoen Clinic Vogtareuth, Germany; Research Institute for Rehabilitation (G.K.), Transition and Palliation, PMU Salzburg, Austria; Department of Neuropediatrics (H.M., M.P.), University Medical Center Schleswig-Holstein, Christian-Albrechts University; Institute of Clinical Molecular Biology (M.P.), Christian-Albrechts-University of Kiel, Germany; The Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Research (R.S.M.), University of Southern Denmark, Odense, Denmark; Institute of Human Genetics (K.P.), University of Leipzig Medical Center, Germany; Wilhelm Johannsen Centre for Functional Genome Research (J.L.S.), Department of Cellular and Molecular Medicine, University of Copenhagen; and Department of Biomedical Sciences (J.L.S.), University of Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Pathogenic variants in Methods: A multicenter, retrospective, cross-sectional cohort study was conducted according to the Strengthening the Reporting of Observational Studies in Epidemiology criteria. Inclusion criteria were occurrence of infantile seizures and genetic diagnosis of likely pathogenic/pathogenic Results: Treatment response data from 52 individuals with Discussion: In conclusion, a favorable effect of most ASMs, especially sodium channel blockers such as carbamezepine and OXC, was observed, whereas the efficacy and the retention rate of LEV was lower in Classification of Evidence: This study provides Class IV evidence that in individuals with

Identifiers

PMID36187725
PMCPMC9520344

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