Evidence map›Paper›PMID 36187617›Full record

ArticleFrontiers in public health2022

Circulating (1 → 3)-β-D-Glucan as an immune activation marker decreased after ART in people living with HIV.

Jingna Xun, Shuyan Guo, Yumin Xu, Rong Chen, Qi Tang, Xinyu Zhang, Danping Liu, Renfang Zhang, Yinzhong Shen, Li Liu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Alterations of the Intestinal Mucosal Barrier and Gut Fungal Microbiome in Asymptomatic HIV-Infected Patients.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024
    Article
  2. Fungal translocation measured by serum 1,3-ß-D-glucan correlates with severity and outcome of liver cirrhosis-A pilot study.Liver international : official journal of the International Association for the Study of the Liver · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Jingna XunDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Shuyan GuoShanghai Foreign Language School, Shanghai International Studies University, Shanghai, China.
Yumin XuDepartment of Infectious Diseases, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Rong ChenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Qi TangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xinyu ZhangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Danping LiuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Renfang ZhangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yinzhong ShenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Li LiuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jiangrong WanDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jun ChenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Hongzhou LuDepartment of Infectious Diseases and Nursing research institution, National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, Guangdong, China.
Shanghai Public Health Clinical Center · CNShanghai International Studies University · CNShanghai Jiao Tong University · CNShenzhen Third People’s Hospital · CNState Key Laboratory of Genetic Engineering

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Plasma level of polysaccharide (1 → 3)-β-D-Glucan (βDG), as a diagnostic marker of invasive fungal infection has been reported to be elevated in people living with HIV (PLWH). We assessed the association of circulating βDG to inflammation and systemic immune activation and the effect of antiretroviral therapy (ART) on βDG in PLWH. Method: Plasma and peripheral blood monocular cell samples from 120 PLWH naive to ART and after 1 year's ART were collected. Plasma levels of βDG, markers of bacterial translocation, gut damage, and cellular immune activation were quantified. Result: The plasma βDG levels were negatively correlated with CD4+ T cells count ( Conclusion: The level of plasma βDG was associated with cellular immune activation and decreased after ART in PLWH, suggesting it could serve as a biomarker of immune activation and efficacy monitoring.

Indexed as

beta-GlucansHIV InfectionsBiomarkersFatty Acid-Binding ProteinsHumansLipopolysaccharide ReceptorsLipopolysaccharidesPancreatitis-Associated ProteinsProgrammed Cell Death 1 Receptorbeta-GlucansBiomarkersFatty Acid-Binding ProteinsLipopolysaccharide ReceptorsLipopolysaccharidesPancreatitis-Associated ProteinsProgrammed Cell Death 1 Receptor(1 → 3)-β-D-GlucanARTHIVimmune activationmicrobial translocation

Identifiers

PMID36187617
PMCPMC9516330
OpenAlexW4295565211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.