Evidence map›Paper›PMID 36187582›Full record

ReviewIndian journal of orthopaedics2022

Bacteriophage Therapy in Implant-Related Orthopedic Infections.

Madhan Jeyaraman, Naveen Jeyaraman, Vijay Kumar Konkathi, Arulkumar Nallakumarasamy, Sathish Muthu, Manish Khanna

Open access · greenAbstract readReview
In one paragraph

Review in Indian journal of orthopaedics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Case reports in orthopedics · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Madhan JeyaramanDepartment of Orthopaedics, Faculty of Medicine, Sri Lalithambigai Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai, Tamil Nadu India.ORCID 0000-0002-9045-9493
Naveen JeyaramanIndian Orthopaedic Rheumatology Association (IORA), Lucknow, India.ORCID 0000-0002-4362-3326
Vijay Kumar KonkathiIndian Orthopaedic Rheumatology Association (IORA), Lucknow, India.
Arulkumar NallakumarasamyIndian Orthopaedic Rheumatology Association (IORA), Lucknow, India.
Sathish MuthuIndian Orthopaedic Rheumatology Association (IORA), Lucknow, India.ORCID 0000-0002-7143-4354
Manish KhannaIndian Orthopaedic Rheumatology Association (IORA), Lucknow, India.ORCID 0000-0002-2890-869X
All India Institute of Medical Sciences Bhubaneswar · INDr. M.G.R. Educational and Research Institute · INDr. Ram Manohar Lohia National Law University · INGovernment Medical College and Hospital · INNational Institute of Technology Tiruchirappalli · INSir Sayajirao General Hospital Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofilm producers pose a major challenge in treating implant-related orthopedic infections (IROIs). The incidence of IROIs for the closed fracture amounts to 1% to 2% whereas for open fracture it is up to 30%. Due to inappropriate and irrational use of antibiotics in the management of infections, there is an emergence of a global "antimicrobial resistance crisis". To combat these antimicrobial resistance crises, a few innovative and targeted therapies like nanomedicine, phage therapy, antimicrobial peptides, and sonic therapies have been introduced. In this review, we have detailed the basic mechanisms involved in the employment of bacteriophage therapy for IROIs, along with the preclinical and clinical data on its utility. We also present the guidelines on its regulation, processing, and limitations of bacteriophage therpay to combat the upcoming era of antibiotic resistance.

Indexed as

Antimicrobial resistanceBacteriophageBiofilm

Identifiers

PMID36187582
PMCPMC9485506
OpenAlexW4293795254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.