Trial reportNeuropsychiatric disease and treatment2022
Preliminary Study of Vagus Nerve Magnetic Modulation in Patients with Prolonged Disorders of Consciousness.
Trial report in Neuropsychiatric disease and treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An individual patient data meta-analysis on vagal nerve stimulation for recovery from disorders of consciousness.Scientific reports · 2026Pooled it
- Multimodal Assessment of Consciousness with Brain-Computer Interfaces and Artificial Intelligence: From Acquired Brain Injury to Neurodegenerative Disease.Journal of clinical medicine · 2026Review
- Case Report: Peripheral combined central dual-target magnetic stimulation for non- motor symptoms of Parkinson's disease.Frontiers in psychiatry · 2025Article
- Cross-frequency coupling patterns during oddball processing in disorders of consciousness: a delta-gamma predominance.Frontiers in psychology · 2025Article
- Feasibility of vagus nerve modulation (VNMM/taVNS) in cognitive-swallowing dual-task paradigms: a fNIRS pilot study.Frontiers in neuroscience · 2025Article
- Exploration of resting-state brain functional connectivity as preclinical markers for arousal prediction in prolonged disorders of consciousness: A pilot study based on functional near-infrared spectroscopy.Brain and behavior · 2024Article
- Transcutaneous vagus nerve stimulation: a bibliometric study on current research hotspots and status.Frontiers in neuroscience · 2024Review
- The accuracy of different mismatch negativity amplitude representations in predicting the levels of consciousness in patients with disorders of consciousness.Frontiers in neuroscience · 2023Article
- Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review.Frontiers in neuroscience · 2023Review
- Effectiveness of coma arousal therapy on patients with disorders of consciousness - A systematic review and meta-analysis.Brain circulationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The number of patients with prolonged disorders of consciousness (pDOC) is increasing. However, its clinical treatment remains challenging. To date, no studies have reported the effect of vagus nerve modulation (VNM) using repetitive transcranial magnetic stimulation (rTMS) in patients with pDOC. We aimed to evaluate the effect of vagus nerve magnetic modulation (VNMM) on pDOC patients. Methods: We performed VNMM in 17 pDOC patients. The Revised Coma Recovery Scale (CRS-R), Glasgow scale (GCS), somatosensory evoked potentials (SEP) and brainstem auditory evoked potentials (BAEP) were assessed before and after treatment. Results: Both CRS-R and GCS results showed significant improvement in p DOC patients after VNMM treatment. The CRS-R improved from 7.88 ± 2.93 to 11.53 ± 4.94. The GCS score also improved from 7.65 ± 1.9 to 9.18 ± 2.65. The number of BAEP grades I increased from 3 to 5 after treatment. The number of BAEP grades I increased from 3 to 5, grade II increased by 1, and grade III decreased from 4 to 1. Conclusion: This study provides a preliminary indication of the potential of VNMM in the rehabilitation of pDOC patients. It provides the basis for a Phase 2 or Phase 3 study of VNMM in patients with pDOC.
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