Evidence map›Paper›PMID 36187555›Full record

ArticleOncotarget2022

Genomic alterations predictive of poor clinical outcomes in pan-cancer.

Crystal S Seldon, Karthik Meiyappan, Hannah Hoffman, Jimmy A Guo, Neha Goel, William L Hwang, Paul L Nguyen, Brandon A Mahal, Mohammed Alshalalfa

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Crystal S SeldonSylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Karthik MeiyappanMiller School of Medicine, University of Miami, Miami, FL 33136, USA.
Hannah HoffmanDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Jimmy A GuoBroad Institute of MIT, Cambridge, MA 02142, USA.
Neha GoelSylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
William L HwangDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Paul L NguyenDana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA 02215, USA.
Brandon A MahalSylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Mohammed AlshalalfaSylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
University of Miami · USSylvester Comprehensive Cancer Center · USBroad Institute · USDana-Farber Cancer Institute · USMassachusetts General Hospital · USUniversity of California, San Francisco · US

Funding

Elucidating cancer-intrinsic mechanisms of perineural invasion in pancreatic cancerK08CA270417 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI William L Hwang · 2022 to 2026
$1.6M
NCI NIH HHS K08 CA270417
6 · The paper itself

Abstract

backgroundGenomic alterations are highly frequent across cancers, but their prognostic impact is not well characterized in pan-cancer cohorts. Here, we use pan-cancer cohorts from TCGA and MSK-IMPACT to evaluate the associations of common genomic alterations with poor clinical outcome. MATERIALS AND

methodsGenomic alterations in commonly altered genes were extracted from Pan-Cancer TCGA and MSK-IMPACT cohorts. Multivariable Cox regression analyses stratified by cancer type defined adjusted hazard ratios (AHRs) for disease-specific survival (DSS), progression-free survival (PFS) and overall survival (OS).

resultsUsing TCGA we identified 32 mutated genes, and 15 copy number (CN) genes with frequency >= 4% in 9,104 patients across 28 cancers. On UVA, having a TP53-mutations or any mutation in the 31 genes (mut31) were associated with worse PFS (HR: 1.22,

conclusionsTP53-mutations, CDKN2A-deletion, PTEN-deletion, and MYC-amplification are independent pan-cancer prognostic genomic alterations.

Indexed as

NeoplasmsDNA Copy Number VariationsGenomicsHumansMutationPrognosisgenomic alterationspoor prognosisTCGATP53

Identifiers

PMID36187555
PMCPMC9518688
OpenAlexW4297473714

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.