Evidence map›Paper›PMID 36187487›Full record

ArticleFrontiers in cell and developmental biology2022

The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis.

Jessica Denise Schwarz, Sören Lukassen, Pranjali Bhandare, Lorenz Eing, Marteinn Thor Snaebjörnsson, Yiliam Cruz García, Jan Philipp Kisker, Almut Schulze, Elmar Wolf

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jessica Denise SchwarzCancer Systems Biology Group, Theodor Boveri Institute, University of Würzburg, Würzburg, Germany.
Sören LukassenCenter for Digital Health, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Pranjali BhandareCancer Systems Biology Group, Theodor Boveri Institute, University of Würzburg, Würzburg, Germany.
Lorenz EingCancer Systems Biology Group, Theodor Boveri Institute, University of Würzburg, Würzburg, Germany.
Marteinn Thor SnaebjörnssonTumor Metabolism and Microenvironment, German Cancer Research Center, Heidelberg, Germany.
Yiliam Cruz GarcíaCancer Systems Biology Group, Theodor Boveri Institute, University of Würzburg, Würzburg, Germany.
Jan Philipp KiskerCancer Systems Biology Group, Theodor Boveri Institute, University of Würzburg, Würzburg, Germany.
Almut SchulzeTumor Metabolism and Microenvironment, German Cancer Research Center, Heidelberg, Germany.
Elmar WolfCancer Systems Biology Group, Theodor Boveri Institute, University of Würzburg, Würzburg, Germany.
University of Würzburg · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEGerman Cancer Research Center · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular growth is a fundamental process of life and must be precisely controlled in multicellular organisms. Growth is crucially controlled by the number of functional ribosomes available in cells. The production of new ribosomes depends critically on the activity of RNA polymerase (RNAP) II in addition to the activity of RNAP I and III, which produce ribosomal RNAs. Indeed, the expression of both, ribosomal proteins and proteins required for ribosome assembly (ribosomal biogenesis factors), is considered rate-limiting for ribosome synthesis. Here, we used genetic screening to identify novel transcriptional regulators of cell growth genes by fusing promoters from a ribosomal protein gene (

Indexed as

AldoAaldolase Agenetic screengenome-wide screenRBM8ARibosomal protein generibosome biogenesisY14

Identifiers

PMID36187487
PMCPMC9515781
OpenAlexW4295572360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.