Evidence map›Paper›PMID 36187462›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2022

Dysbiosis and Depletion of Fecal Organic Acids Correlate With the Severity of Rejection After Rat Liver Transplantation.

Siyuan Yao, Shintaro Yagi, Eri Ogawa, Masaaki Hirata, Yosuke Miyachi, Sena Iwamura, Ryuji Uozumi, Takuya Sugimoto, Takashi Asahara, Shinji Uemoto and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. The Role of Gut Microbiota in Liver Regeneration After Partial Hepatectomy: New Evidence From Animal and Human Studies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Siyuan YaoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shintaro YagiDepartment of Surgery, Graduate School of Medicine, Kanazawa University, Ishikawa, Japan.
Eri OgawaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Masaaki HirataDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yosuke MiyachiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sena IwamuraDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ryuji UozumiDepartment of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takuya SugimotoYakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan.
Takashi AsaharaYakult Central Institute, Yakult Honsha Co., Ltd., Tokyo, Japan.
Shinji UemotoShiga University of Medical Science, Otsu, Japan.
Etsuro HatanoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kyoto University · JPKanazawa University · JPShiga University of Medical Science · JPYakult Central Institute · JPYakult Honsha (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of T cell-mediated rejection (TCMR) after liver transplantation (LT) on the alterations in the gut microbiota (GM) and associated intestinal environment represented by fecal organic acids (OAs) require further elucidation. A rat allogeneic LT model was prepared without immunosuppressants or antibiotics, and a syngeneic model was used as a control. Qualitative and quantitative analyses of fecal samples at fixed time points were performed. Correlation analyses were also performed between liver function and GMs and OA levels. In the allogeneic TCMR group, the number of predominant obligate anaerobes decreased as liver function declined.

Indexed as

DysbiosisLiver TransplantationAlanine TransaminaseAnimalsAnti-Bacterial AgentsBilirubinFatty Acids, VolatileImmunosuppressive AgentsRatsAlanine TransaminaseAnti-Bacterial AgentsBilirubinFatty Acids, VolatileImmunosuppressive Agentsdysbiosispredominant obligate anaerobesribosomal RNA-targeted reverse-transcription quantitative polymerase chain reactionshort-chain fatty acidT cell-mediated rejection

Identifiers

PMID36187462
PMCPMC9519788
OpenAlexW4295926213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.