Evidence map›Paper›PMID 36187399›Full record

ArticleWorld journal of gastrointestinal oncology2022

Prognostic and clinicopathological value of Twist expression in esophageal cancer: A meta-analysis.

Wen-Peng Song, Su-Yan Wang, Si-Cheng Zhou, Dong-Sheng Wu, Jia-Yu Xie, Tong-Tong Liu, Xiu-Zhu Wu, Guo-Wei Che

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In one paragraph

Article in World journal of gastrointestinal oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Wen-Peng SongLung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Su-Yan WangFrontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Si-Cheng ZhouWest China School of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China.
Dong-Sheng WuWest China School of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China.
Jia-Yu XieLaboratory Experiments in Microbiology, Shuang Liu Center for Disease Control and Prevention, Chengdu 610041, Sichuan Province, China.
Tong-Tong LiuWest China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Xiu-Zhu WuWest China School of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China.
Guo-Wei CheLung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. cheguoweixw@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTwist is a repressor of E-cadherin transcription that induces epithelial-mesenchymal transition and cancer metastasis. However, the prognostic value of Twist expression in patients with esophageal cancer remains controversial.

aimTo investigate the prognostic and clinicopathological value of Twist expression in esophageal cancer.

methodsPublished literature in databases such as EMBASE, Web of Science, PubMed, China National Knowledge Infrastructure, Wanfang, and VIP databases was searched for eligible articles. Participants with esophageal cancer whose tumor tissues underwent immunohistochemistry to detect the expression of Twist were considered. Our meta-analysis was conducted using Stata version 12.0. The hazard ratio (HR) and relative ratio (RR) with their 95%CI were pooled. Heterogeneity was estimated by

resultsEleven articles published between 2009 and 2021 fulfilled the selection criteria. The pooled HR for overall survival was 1.88 (95%CI: 1.32-2.69,

conclusionHigh expression of Twist is associated with poor esophageal cancer prognosis. Moreover, Twist overexpression is correlated with T stage, lymph node metastasis, distant metastasis, TNM stage, and clinical stage, which indicates that Twist might accelerate esophageal cancer progression and metastasis.

Indexed as

Epithelial-mesenchymal transitionEsophageal cancerMeta-analysisMetastasisPrognosisTwist

Identifiers

PMID36187399
PMCPMC9516646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.