ArticleWorld journal of gastrointestinal oncology2022
Prognostic impact of tumor deposits on overall survival in colorectal cancer: Based on Surveillance, Epidemiology, and End Results database.
Article in World journal of gastrointestinal oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Development and validation of a nomogram for preoperative prediction of tumor deposits in colorectal cancer.World journal of gastroenterology · 2023Trial
- Independent prognostic value of tumor deposits in stage III colorectal cancer: a large-scale systematic review and meta-analysis.Journal of gastrointestinal oncology · 2026Article
- D3 lymph node dissection in right-sided colon cancer: routine requirement or selective application?Journal of gastrointestinal oncology · 2025Article
- Tumour deposit count is an independent prognostic factor in colorectal cancer-a population-based cohort study.The British journal of surgery · 2024Article
- Prognostic and predictive value of tumor deposits in advanced signet ring cell colorectal cancer: SEER database analysis and multicenter validation.World journal of surgical oncology · 2024Article
- The development and implementation of pathological parameters and molecular testing impact prognosis of colorectal adenocarcinoma.Journal of the National Cancer Center · 2024Article
- Negative prognostic impact of tumor deposits in stage III colorectal cancer patients.PloS one · 2024Article
- A nomogram prediction model based on clinicopathological combined radiological features for metachronous liver metastasis of colorectal cancer.Journal of Cancer · 2024Article
- [Prognostic histological markers in colorectal cancer].Pathologie (Heidelberg, Germany) · 2023Review
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7 authors.
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Abstract
backgroundIn colorectal cancer, tumor deposits (TDs) are considered to be a prognostic factor in the current staging system, and are only considered in the absence of lymph node metastases (LNMs). However, this definition and the subsequent prognostic value based on it is controversial, with various hypotheses. TDs may play an independent role when it comes to survival and addition of TDs to LNM count may predict the prognosis of patients more accurately.
aimTo assess the prognostic impact of TDs and evaluate the effect of their addition to the LNM count.
methodsThe patients are derived from the Surveillance, Epidemiology, and End Results database. A prognostic analysis regarding impact of TDs on overall survival (OS) was performed using Cox regression model, and other covariates associating with OS were adjusted. The effect of addition of TDs to LNM count on N restaging was also evaluated. The subgroup analysis was performed to explore the different profile of risk factors between patients with and without TDs.
resultsOverall, 103755 patients were enrolled with 14131 (13.6%) TD-positive and 89624 (86.4%) TD-negative tumors. TD-positive patients had worse prognosis compared with TD-negative patients, with 3-year OS rates of 47.3% (95%CI, 46.5%-48.1%) and 77.5% (95%CI, 77.2%-77.8%,
conclusionTDs are an independent prognostic factor for OS in colorectal cancer. The addition of TDs to LNM count improved the prognostic accuracy of tumor, node and metastasis staging.
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