ArticleWorld journal of gastrointestinal oncology2022
Prediction of gastric cancer risk by a polygenic risk score of
Article in World journal of gastrointestinal oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Risk Prediction Models for Gastric Cancer: A Scoping Review.Journal of multidisciplinary healthcare · 2024Article
- Evaluation of polygenic risk score for risk prediction of gastric cancer.World journal of gastrointestinal oncology · 2023Review
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Authors and funding
8 authors.
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Abstract
backgroundGenetic variants of
aimTo assess the performance of a polygenic risk score (PRS) based on
methodsA total of 15 gastric cancer-associated
resultsAnalyses of the association between selected SNPs and gastric cancer in the global dataset revealed that the risk allele frequencies of six SNPs were significantly higher in gastric cancer cases than non-gastric cancer cases. The PRS model constructed subsequently with these validated SNPs produced significantly higher scores in gastric cancer. The odds ratio (OR) value for gastric cancer gradually increased from the first to the fifth quintile of PRS, with the fifth quintile having an OR value as high as 9.76 (95% confidence interval: 5.84-16.29). The results of RF analyses indicated that the area under the curve (AUC) value for classifying gastric cancer and non-gastric cancer was 0.75, suggesting that the PRS based on
conclusionThe PRS model based on
Indexed as
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