Evidence map›Paper›PMID 36187365›Full record

ArticleTherapeutic advances in gastroenterology2022

A randomized controlled trial of a multicomponent online stress reduction intervention in inflammatory bowel disease.

Farhad Peerani, Makayla Watt, Kathleen P Ismond, Reid Whitlock, Lindsy Ambrosio, Naomi Hotte, Nicholas Mitchell, Robert J Bailey, Karen Kroeker, Levinus A Dieleman and 9 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03831750 (Assessing the Effectiveness of a Stress Reduction Intervention in Inflammatory Bowel Disease), which is not on this map. Cited by 24 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03831750 nacompletednot on this map

Assessing the Effectiveness of a Stress Reduction Intervention in Inflammatory Bowel Disease (IBD): a Prospective Randomized Controlled Trial (RCT)

TypeinterventionalSponsorUniversity of AlbertaRan2019 to 2021Enrolled101ConditionsInflammatory Bowel Diseases, Remission, Perceived StressArmsStress Reduction Intervention
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Psychological interventions for treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Farhad PeeraniDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Makayla WattDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Kathleen P IsmondDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Reid WhitlockChronic Disease Innovation Centre, Seven Oaks General Hospital, Winnipeg, MB, Canada.
Lindsy AmbrosioDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Naomi HotteDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Nicholas MitchellDepartment of Psychiatry, University of Alberta, Edmonton, AB, Canada.
Robert J BaileyDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Karen KroekerDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Levinus A DielemanDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Jesse SiffledeenDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Allen LimDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Karen WongDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Brendan P HalloranDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Daniel C BaumgartDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Lorian TaylorDivision of Gastroenterology, University of Calgary, Calgary, AB, Canada.
Maitreyi RamanDivision of Gastroenterology, University of Calgary, Calgary, AB, Canada.ORCID https://orcid.org/0000-0002-9129-3632
Karen L MadsenDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Puneeta TandonDivision of Gastroenterology, Department of Medicine, University of Alberta, 130 University Campus NW, Edmonton, AB T6G 2X8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Psychological stress negatively impacts inflammatory bowel disease (IBD) outcomes. Patients have prioritized access to online interventions; yet, the data on these have been limited by mixed in-person/online interventions, low adherence, and non-randomized controlled trial (RCT) design. Objectives: We assessed the efficacy of and adherence to a 12-week online multicomponent stress reduction intervention in IBD. Design: This is a RCT. Methods: Adult participants on stable IBD medical therapy with elevated stress levels from four centers were randomized to intervention or control groups. Intervention participants received a 12-week online program including a weekly yoga, breathwork and meditation video (target 2-3 times/week), a weekly cognitive behavioral therapy/positive psychology informed video activity, and weekly 10-min check-ins by a study team member. Control participants received weekly motivational messages by email. All patients received standard of care IBD therapy. The primary outcome was Cohen's Perceived Stress Scale (PSS). Secondary outcomes evaluated mental health, resilience, health-related quality of life (HRQoL), symptom indices, acceptability, adherence, and inflammatory biomarkers. Analysis of covariance was used to determine between-group differences. Results: Of 150 screened patients, 101 were randomized to the intervention ( Conclusion: This 12-week online intervention improved perceived stress, mental health, and HRQoL, but did not impact IBD symptom indices or inflammatory biomarkers. The program was readily adopted and adhered to by participants with high retention rates. After iterative refinement based on participant feedback, future studies will evaluate the impact of a longer/more intense intervention on disease course. Registration: ClinicalTrials.gov Identifier NCT03831750. Plain Language Summary:

Indexed as

inflammatory bowel diseaseonline interventionstress reduction

Identifiers

PMID36187365
PMCPMC9520184

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.