Evidence map›Paper›PMID 36187337›Full record

ArticleOxidative medicine and cellular longevity2022

Fecal Microbiota Transplantation Combined with a Low FODMAP Diet for the Treatment of Irritable Bowel Syndrome with Predominant Diarrhea.

Hong-Li Huang, Jia-Qi Zhu, Liu-Si Yang, Qiong Wu, Di-Wen Shou, Hui-Ting Chen, Jun Ma, Yong-Qiang Li, Hao-Ming Xu, Yong-Jian Zhou

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hong-Li HuangDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.ORCID https://orcid.org/0000-0002-5882-1106
Jia-Qi ZhuDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.ORCID https://orcid.org/0000-0003-1592-3329
Liu-Si YangDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.ORCID https://orcid.org/0000-0002-9796-9568
Qiong WuDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.ORCID https://orcid.org/0000-0002-7968-4534
Di-Wen ShouDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.ORCID https://orcid.org/0000-0002-7489-7231
Hui-Ting ChenDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.ORCID https://orcid.org/0000-0003-0380-7822
Jun MaDepartment of Traditional Chinese Medicine, Guangzhou First People's Hospital, Guangzhou 510180, China.ORCID https://orcid.org/0000-0001-5442-3349
Yong-Qiang LiDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.ORCID https://orcid.org/0000-0002-8527-032X
Hao-Ming XuDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.ORCID https://orcid.org/0000-0002-8131-7477
Yong-Jian ZhouDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.ORCID https://orcid.org/0000-0003-1721-7639

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fecal microbiota transplantation (FMT) has been found to be effective in irritable bowel syndrome with predominant diarrhea (IBS-D). We conducted this study to determine the impact of a low FODMAP diet (LFD) on the gut microbiota and the efficacy of FMT in the treatment of IBS-D. Methods: A retrospective analysis of a single-arm open-label prospective study was conducted to investigate the impact of FMT alone ( Results: The response rates were higher in the FMT+LFD group than in the FMT group (1 mo, 3 mo, 6 mo: 70.0% vs. 55.0%, 67.5% vs. 57.5%, 62.5% vs. 27.5%, respectively). The FMT+LFD group showed significantly better improvement in IBS-QOL at 1, 3, and 6 months; IBS-SSS at 6 months; and GSRS at 1 month compared to FMT alone. Changes in HAMA and HAMD were similar in the two groups. The LFD significantly upregulated the FMT-induced microbial diversity (OTUs: 666 vs. 574, Adonis: Conclusion: An LFD enhanced the efficacy of FMT, increased the gut microbial diversity after FMT, and strengthened the inhibitory effect of FMT on conditional pathogens.

Indexed as

Gastrointestinal DiseasesIrritable Bowel SyndromeDiarrheaDietDNA, RibosomalFecal Microbiota TransplantationFecesHumansProspective StudiesQuality of LifeRetrospective StudiesDNA, Ribosomal

Identifiers

PMID36187337
PMCPMC9519354

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.