Evidence map›Paper›PMID 36187327›Full record

ReviewNature and science of sleep2022

Effects of Melatonin Treatment on Perioperative Sleep Quality: A Systematic Review and Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials.

Yi Gao, Xuezhao Chen, Qi Zhou, Jiannan Song, Xizhe Zhang, Yi Sun, Miao Yu, Yun Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature and science of sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  19. Perioperative Anxiety and Depression in Older Adults: Epidemiology and Treatment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yi Gao *Chifeng Clinical Medical College of Inner Mongolia Medical University, Chifeng, People's Republic of China.ORCID 0000-0002-0217-7067
Xuezhao Chen *First Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.ORCID 0000-0003-3272-8840
Qi ZhouChifeng Clinical Medical College of Inner Mongolia Medical University, Chifeng, People's Republic of China.
Jiannan SongChifeng Clinical Medical College of Inner Mongolia Medical University, Chifeng, People's Republic of China.
Xizhe ZhangChifeng Clinical Medical College of Inner Mongolia Medical University, Chifeng, People's Republic of China.
Yi SunChifeng Clinical Medical College of Inner Mongolia Medical University, Chifeng, People's Republic of China.
Miao YuChifeng Clinical Medical College of Inner Mongolia Medical University, Chifeng, People's Republic of China.
Yun LiChifeng Clinical Medical College of Inner Mongolia Medical University, Chifeng, People's Republic of China.ORCID 0000-0001-7989-805X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Perioperative sleep disorders have attracted much attention due to their high prevalence and severe harm, and the current treatment methods are insufficient. Some randomized controlled trials (RCTs) have produced controversial results on whether melatonin can improve perioperative sleep quality. This review aimed to evaluate the effects of melatonin treatment on perioperative sleep quality. Patients and Methods: A systematic search of six databases was performed to identify RCTs investigating melatonin and perioperative sleep. The outcomes analyzed were subjective sleep quality, sleep latency (SL), total sleep time (TST), sleep efficiency (SE), the behavior of awakenings and daily naps, and the incidence of poor sleep quality. RevMan 5.4 and Stata 16 software was used for the meta-analysis and sensitivity analysis, and trial sequential analysis was conducted using TSA 0.9.5.10 Beta software. This study was registered in PROSPERO (registration number: CRD42022311378). Results: 10 studies containing 725 participants were included. Melatonin improved postoperative subjective sleep quality (SMD: -0.30; 95% CI: [-0.47, -0.14]; P = 0.0004) but not preoperative sleep quality (MD: -2.76; 95% CI: [-10.44, 4.91]; P = 0.48). In the postoperative period, 6mg dose had the best efficacy (SMD: -0.31; 95% CI: [-0.57, -0.04]; P = 0.02). Melatonin increased postoperative TST (P = 0.02) and SE (P = 0.002) and decreased the incidence of postoperative poor sleep quality (P = 0.002) but had no effect on SL (P = 0.11), the number and duration of awakenings (P = 0.28; P=0.55), and the number and duration of daily naps (P = 0.26; P = 0.38). The trial sequential analysis showed that the accumulated Z value crossed both the traditional boundary value and the TSA boundary value, further confirming the stability of the result of the meta-analysis. Conclusion: Melatonin treatment can improve postoperative sleep quality. A 6mg daily dose of melatonin may have a better beneficial effect, which needs further exploration. This study supports the application of melatonin for improving postoperative sleep quality.

Indexed as

melatoninmeta-analysisperioperativepostoperativepreoperativesleep quality

Identifiers

PMID36187327
PMCPMC9519126

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.