Evidence map›Paper›PMID 36187288›Full record

ArticleFrontiers in cellular neuroscience2022

N-Methyl D-aspartate receptor subtype 2B/Ca

Zi-Fan Zhuang, Hong-Yun Wu, Ya-Yi Song, Lei Li, Xia Cui, Jie Yang, Xiang-Qing Xu, Wen-Qiang Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zi-Fan ZhuangCollege of First Clinical Medicine, Beijing University of Chinese Medicine, Beijing, China.
Hong-Yun WuDepartment of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Ya-Yi SongDepartment of Traditional Chinese Medicine, Lianyungang Maternal and Child Health Hospital, Lianyungang, China.
Lei LiDepartment of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Xia CuiDepartment of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Jie YangDepartment of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Xiang-Qing XuDepartment of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Wen-Qiang CuiDepartment of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trigeminal neuralgia (TN) is a peripheral nerve disorder often accompanied by abnormalities in mood. The lateral habenula (LHb) plays important roles in the modulation of pain and emotion. In the present study, we investigated the involvement of the LHb in the mechanisms underlying allodynia and anxiety induced by partial transection of the infraorbital nerve (pT-ION) in mice. Our results indicated that pT-ION induced persistent orofacial allodynia and anxiety-like behaviors, which were correlated with increased phosphorylation of N-Methyl D-aspartate receptor (NMDAR) subtype 2B (p-NR2B) and Ca

Indexed as

anxietyCa2+/calmodulin-dependent protein kinase II (CaMKII)lateral habenulaN-methyl-D-aspartate receptor (NMDAr)trigeminal neuralgia

Identifiers

PMID36187288
PMCPMC9521491

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.