Evidence map›Paper›PMID 36187145›Full record

ReviewEpilepsy currents

Current Review in Basic Science: Animal Models of Focal Cortical Dysplasia and Epilepsy.

Lena H Nguyen, Angélique Bordey

Abstract readReview
In one paragraph

Review in Epilepsy currents. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Focal postnatal deletion ofFrontiers in molecular neuroscience · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. The mTOR pathway genesbioRxiv : the preprint server for biology · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lena H NguyenDepartments of Neurosurgery and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-4463-7164
Angélique BordeyDepartments of Neurosurgery and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-3496-3385

Funding

Epilepsy in Focal Cortical MalformationsR01NS111980 · NINDS · YALE UNIVERSITY · PI BORDEY, ANGELIQUE, CALDERWOOD, DAVID A · 2019 to 2023
$2.3M
mTORC1-dependent translational control in developmental epilepsyF32HD095567 · NICHD · YALE UNIVERSITY · PI NGUYEN, LENA · 2018 to 2021
$197k
NICHD NIH HHS F32 HD095567NINDS NIH HHS R01 NS111980
6 · The paper itself

Abstract

Focal cortical dysplasia (FCD) is a malformation of cortical development that is a prevalent cause of intractable epilepsy in children. Of the three FCD subtypes, understanding the etiology and pathogenesis of FCD type II has seen the most progress owing to the recent advances in identifying gene mutations along the mTOR signaling pathway as a frequent cause of this disorder. Accordingly, numerous animal models of FCD type II based on genetic manipulation of the mTOR signaling pathway have emerged to investigate the mechanisms of epileptogenesis and novel therapeutics for epilepsy. These include transgenic and

Indexed as

astrocytescortical developmentcortical lesionCRISPR/Cas9in utero electroporationmalformation of cortical developmentpyramidal neuronsseizuretransgenic mice

Identifiers

PMID36187145
PMCPMC9483763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.