Evidence map›Paper›PMID 36186973›Full record

ArticleFrontiers in cardiovascular medicine2022

Effects of the flow diversion technique on nucleotide levels in intra-cranial aneurysms: A feasibility study providing new research perspectives.

Omer F Eker, Boris Lubicz, Melissa Cortese, Cedric Delporte, Moncef Berhouma, Bastien Chopard, Vincent Costalat, Alain Bonafé, Catherine Alix-Panabières, Pierre Van Anwterpen and 1 more

Abstract read
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Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Omer F EkerDepartment of Neuroradiology, Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France.
Boris LubiczDepartment of Interventional Neuroradiology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Melissa CorteseRD3-Pharmacognosy, Bioanalysis, and Drug Discovery and Analytical Platform, Faculty of Pharmacy, Université Libre de Bruxelles, Brussels, Belgium.
Cedric DelporteRD3-Pharmacognosy, Bioanalysis, and Drug Discovery and Analytical Platform, Faculty of Pharmacy, Université Libre de Bruxelles, Brussels, Belgium.
Moncef BerhoumaDepartment of Vascular Neurosurgery, Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France.
Bastien ChopardScientific and Parallel Computing Group, CUI, University of Geneva, Geneva, Switzerland.
Vincent CostalatDepartment of Neuroradiology, Hôpital Gui de Chauliac, Montpellier, France.
Alain BonaféDepartment of Neuroradiology, Hôpital Gui de Chauliac, Montpellier, France.
Catherine Alix-PanabièresLaboratory of Rare Human Circulating Cells, University Medical Center of Montpellier, University of Montpellier, Montpellier, France.
Pierre Van AnwterpenRD3-Pharmacognosy, Bioanalysis, and Drug Discovery and Analytical Platform, Faculty of Pharmacy, Université Libre de Bruxelles, Brussels, Belgium.
Karim Zouaoui BoudjeltiaLaboratory of Experimental Medicine (ULB 222), Medicine Faculty, Université Libre de Bruxelles, CHU de Charleroi, Charleroi, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The flow diverter stent (FDS) has become a first-line treatment for numerous intra-cranial aneurysms (IAs) by promoting aneurysm thrombosis. However, the biological phenomena underlying its efficacy remain unknown. We proposed a method to collect Materials and methods: In total, 14 patients with unruptured IAs who were selected for FDS implantation were prospectively recruited from February 2015 to November 2015. Two catheters dedicated to (1) FDS deployment and (2) the aneurysm sac were used to collect blood samples within the parent artery (P1) and the aneurysm sac before (P2) and after (P3) flow diversion treatment. The plasma levels of adenosine monophosphate (AMP), adenosine diphosphate (ADP), and adenosine triphosphate (ATP) at each collection point were quantified with liquid chromatography and tandem mass spectrometry. Results: The aneurysms were extradural in nine (64.3%) patients and intra-dural in five (35.7%) patients. They presented an average diameter of 15.5 ± 7.1 mm, height of 15.8 ± 4.6 mm, and volume of 2,549 ± 2,794 ml. In all patients (100%), 16 FDS implantations and 42 Conclusion:

Indexed as

flow diversionin situ blood collectionintra-cranial aneurysmnucleotidesthrombosis – etiology

Identifiers

PMID36186973
PMCPMC9515454

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.