ArticleReumatologia2022
Effect of whole body cryotherapy on low back pain and release of endorphins and stress hormones in patients with lumbar spine osteoarthritis.
Article in Reumatologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Whole-body cryotherapy can reduce the inflammatory response in humans: a meta-analysis based on 11 randomized controlled trials.Scientific reports · 2025Pooled it
- Cryo-Induced Hypoalgesia: The Effects of an Acute Cryochamber Exposure on Pain Perception-A Randomised Controlled Cross-Over Trial.European journal of pain (London, England) · 2025Trial
- Whole-Body Cryostimulation in Complex Regional Pain Syndrome: A Case Study.Journal of clinical medicine · 2026Article
- [Whole-body cryotherapy for low back pain].Orthopadie (Heidelberg, Germany) · 2026Review
- Effects of Whole-Body Cryostimulation on Stress Biomarkers and Psychological Well-Being in Parkinson's Disease: A Pilot Study.Journal of clinical medicine · 2026Article
- Cryotherapy and thermotherapy in the management of osteoarthritis and rheumatoid arthritis: A comprehensive review.Fundamental research · 2025Review
- Impact of Whole-Body Cryotherapy on Pain, Sleep Quality, Functional Status, and Quality of Life in Multiple Sclerosis: A Comparative Study with Follow-Up.Journal of personalized medicine · 2025Article
- Whole-body cryostimulation exposures effectively alleviates menstrual-related pain and associated sleep disturbances in young women: a randomized controlled trial.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Effects of whole-body cryostimulation on spinal and shoulder range of motion in individuals with obesity.Frontiers in rehabilitation sciences · 2025Article
- Whole Body Cryostimulation: A New Adjuvant Treatment in Central Sensitization Syndromes? An Expert Opinion.Healthcare (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Low back pain (LBP) is the most common ailment in patients with lumbar spine osteoarthritis (OA). There are many methods to treat LBP, such as manual therapy, osteopathy, massage, physical exercise, and physical therapy. The most effective of these are manual therapy and exercises combined with physical procedures, such as whole body cryotherapy (WBCT). Whole body cryotherapy can induce various hormonal adaptations in patients with OA. This is probably the body's reaction to cold and stress. The purpose of the study was to evaluate the impact of WBCT on β-endorphins, cortisol and adrenaline release, as well as on LBP in patients with OA of the lumbar spine. Material and methods: The study group consisted of 30 patients with lumbar spine OA who underwent a series of WBCT combined with therapeutic exercises. Before and after the therapy each patient was examined using a visual analogue scale (VAS) and blood samples were collected for laboratory determinations (ELISA). Results: After WBCT, the decrease in LBP measured by VAS was statistically significant ( Conclusions: Whole body cryotherapy combined with therapeutic exercises had a positive effect on LBP reduction in patients with OA. On the basis of these changes, processes that take place in the nervous and endocrine systems are a response to the stimuli of cold and stress. The mechanism of action of extremely low temperatures on the human body is still not fully understood.
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