Evidence map›Paper›PMID 36186825›Full record

ReviewFrontiers in medicine2022

A multidisciplinary approach to the diagnosis of antisynthetase syndrome.

Matthew Wells, Sughra Alawi, Kyaing Yi Mon Thin, Harsha Gunawardena, Adrian R Brown, Anthony Edey, John D Pauling, Shaney L Barratt, Huzaifa I Adamali

Abstract readReview
In one paragraph

Review in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. A Review of Antisynthetase Syndrome-Associated Interstitial Lung Disease.International journal of molecular sciences · 2024
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew WellsDepartment of Rheumatology, North Bristol NHS Trust, Bristol, United Kingdom.
Sughra AlawiBristol Interstitial Lung Disease Service, North Bristol NHS Trust, Bristol, United Kingdom.
Kyaing Yi Mon ThinBristol Interstitial Lung Disease Service, North Bristol NHS Trust, Bristol, United Kingdom.
Harsha GunawardenaDepartment of Rheumatology, North Bristol NHS Trust, Bristol, United Kingdom.
Adrian R BrownImmunology Laboratory, North Bristol NHS Trust, Bristol, United Kingdom.
Anthony EdeyBristol Interstitial Lung Disease Service, North Bristol NHS Trust, Bristol, United Kingdom.
John D PaulingDepartment of Rheumatology, North Bristol NHS Trust, Bristol, United Kingdom.
Shaney L BarrattBristol Interstitial Lung Disease Service, North Bristol NHS Trust, Bristol, United Kingdom.
Huzaifa I AdamaliBristol Interstitial Lung Disease Service, North Bristol NHS Trust, Bristol, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antisynthetase syndrome is a subtype of idiopathic inflammatory myopathy, strongly associated with the presence of interstitial lung disease. Diagnosis is made by identifying myositis-specific antibodies directed against aminoacyl tRNA synthetase, and relevant clinical and radiologic features. Given the multisystem nature of the disease, diagnosis requires the careful synthesis of subtle clinical and radiological features with the interpretation of specialized autoimmune serological testing. This is provided in a multidisciplinary environment with input from rheumatologists, respiratory physicians, and radiologists. Differentiation from other idiopathic interstitial lung diseases is key; treatment and prognosis differ between patients with antisynthetase syndrome and idiopathic interstitial lung disease. In this review article, we look at the role of the multidisciplinary team and its individual members in the initial diagnosis of the antisynthetase syndrome, including the role of physicians, radiologists, and the wider team.

Indexed as

antisynthetase syndromearthritisconnective tissue diseaseinterstitial lung diseasemultidisciplinary teammyositis

Identifiers

PMID36186825
PMCPMC9515890

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.