Evidence map›Paper›PMID 36186791›Full record

ArticleFrontiers in medicine2022

Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot study.

Radmila Karan, Natasa Kovačević-Kostić, Bratislav Kirćanski, Jelena Čumić, Duško Terzić, Vladimir Milićević, Vojislav Velinović, Miloš Velinović, Biljana Obrenović-Kirćanski

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Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Radmila KaranFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Natasa Kovačević-KostićFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Bratislav KirćanskiFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Jelena ČumićFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Duško TerzićFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Vladimir MilićevićClinic for Cardiac Surgery, Clinical Center of Serbia, Belgrade, Serbia.
Vojislav VelinovićClinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia.
Miloš VelinovićFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Biljana Obrenović-KirćanskiFaculty of Medicine, University of Belgrade, Belgrade, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of our study was to evaluate the degree of genetic homozygosity in cardiac surgical patients with postoperative acute kidney injury (AKI), compared to the subgroup without postoperative AKI, as well as to evaluate antropomorpho-genetic variability in cardiac surgical patients with regard to the presence and severity degree of AKI. Materials and methods: The prospective cohort study included an analysis of 138 eligible coronary artery disease (CAD) surgical patients that were screened consecutively. The tested group was divided into three subgroups according to RIFLE criteria: Subgroup NoAKI ( Results: Comparing subgroups NoAKI and risk, four ORHTs were significantly more frequent in the risk subgroup. Comparing subgroups NoAKI and injury, nine ORHTs were significantly more frequent in the injury subgroup; while comparing the injury subgroup and risk, five ORHTs were significantly more frequent in injury than in the risk subgroup. Results also showed a significant increase in the mean value of ORHTs for the injury subgroup compared to NoAKI subgroup ( Conclusion: Our findings pointed to the higher degree of recessive homozygosity and decreased variability in AKI patients vs. NoAKI individuals, thus presumably facilitating the development and severity degree expression of AKI in patients after cardiac surgery.

Indexed as

acute kidney injurycardiac surgerycoronary artery diseaseobservable recessive human traitsvariability

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PMID36186791
PMCPMC9523005

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