Evidence map›Paper›PMID 36186774›Full record

ArticleFrontiers in medicine2022

Association of adenosine signaling gene signature with estrogen receptor-positive breast and prostate cancer bone metastasis.

Daniel Brian Shropshire, Francisca M Acosta, Kun Fang, Jaime Benavides, Lu-Zhe Sun, Victor X Jin, Jean X Jiang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Daniel Brian ShropshireDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, United States.
Francisca M AcostaDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, United States.
Kun FangDivision of Biostatistics and MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI, United States.
Jaime BenavidesDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, United States.
Lu-Zhe SunDepartment of Cell Systems and Anatomy, University of Texas Health Science Center, San Antonio, TX, United States.
Victor X JinDivision of Biostatistics and MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI, United States.
Jean X JiangDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, United States.
The University of Texas Health Science Center at San Antonio · USMedical College of Wisconsin · US

Funding

Systems Analysis of Epigenomic Architecture in Cancer ProgressionU54CA217297 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HUANG, TIM H.-M. · 2017 to 2021
$9.3M
Omics analysis of three-dimensional transcriptional regulationR01GM114142 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JIN, VICTOR, LIN, SHILI · 2015 to 2024
$2.7M
Connexin hemichannels in suppression of breast cancer bone metastasisR01CA196214 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JIANG, JEAN X, SUN, LUZHE · 2016 to 2020
$1.8M
THE FEASIBILITY STUDIES FOR COLLABORATIVE INTERACTION FOR MINORITY INSTITUTE/CANP20CA165589 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LEACH, ROBIN JEAN · 2012 to 2015
$777k
NCI NIH HHS P20 CA165589NCI NIH HHS R01 CA196214NCI NIH HHS U54 CA217297NIGMS NIH HHS R01 GM114142
6 · The paper itself

Abstract

Bone metastasis is a common and devastating consequence of several major cancer types, including breast and prostate. Osteocytes are the predominant bone cell, and through connexin (Cx) 43 hemichannels release ATP to the bone microenvironment that can be hydrolyzed to adenosine. Here, we investigated how genes related to ATP paracrine signaling are involved in two common bone-metastasizing malignancies, estrogen receptor positive (ER

Indexed as

bonebreastmetastasisosteocyteprostatepurinergic

Identifiers

PMID36186774
PMCPMC9520286
OpenAlexW4296099156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.