Evidence map›Paper›PMID 36186751›Full record

ArticleWorld journal of methodology2022

Microvessel density in differentiated thyroid carcinoma: A systematic review and meta-analysis.

Konstantinos Perivoliotis, Athina A Samara, Prodromos Koutoukoglou, Panagiotis Ntellas, Katerina Dadouli, Sotirios Sotiriou, Maria Ioannou, Konstantinos Tepetes

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Article in World journal of methodology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Konstantinos PerivoliotisDepartment of Surgery, University Hospital of Larissa, Larissa 41110, Greece.
Athina A SamaraDepartment of Surgery, University Hospital of Larissa, Larissa 41110, Greece. at.samara93@gmail.com.
Prodromos KoutoukoglouPostgraduate Programme Research Methodology in Biomedicine, Biostatistics and Clinical Bioinformatics, University of Thessaly, Larissa 41110, Greece.
Panagiotis NtellasDepartment of Pathology, University of Thessaly, Larissa 41100, Greece.
Katerina DadouliPostgraduate Programme Research Methodology in Biomedicine, Biostatistics and Clinical Bioinformatics, University of Thessaly, Larissa 41110, Greece.
Sotirios SotiriouDepartment of Embryology, University of Thessaly, Larissa 41100, Greece.
Maria IoannouDepartment of Pathology, University of Thessaly, Larissa 41100, Greece.
Konstantinos TepetesDepartment of Surgery, University Hospital of Larissa, Larissa 41110, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicrovessel density (MVD) has been proposed as a direct quantification method of tumor neovascularization. However, the current literature regarding the role of MVD in differentiated thyroid carcinoma (DTC) remains inconclusive.

aimTo appraise the effect of tumoral MVD on the survival of patients with DTC.

methodsThis meta-analysis was based on the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. The electronic databases Medline, Web of Science, and Scopus were systematically screened. A fixed-effects or random-effects model was used, according to the Cochran

resultsA total of nine studies were included in the present study. Superiority of low MVD tumors in terms of 10-year disease free survival (OR: 0.21, 95%CI: 0.08-0.53) was recorded. Lowly vascularized thyroid cancers had a lower recurrence rate (OR: 13.66, 95%CI: 3.03-61.48). Moreover, relapsing tumors [weighed mean difference (WMD): 11.92, 95%CI: 6.32-17.52] or malignancies with regional lymph node involvement (WMD: 8.53, 95%CI: 0.04-17.02) presented with higher tumoral MVD values.

conclusionMVD significantly correlates with the survival outcomes of thyroid cancer patients. However, considering several study limitations, further prospective studies of higher methodological and quality level are required.

Indexed as

CancerDensityMicrovesselThyroidVascularization

Identifiers

PMID36186751
PMCPMC9516550

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