Evidence map›Paper›PMID 36186719›Full record

ArticlePulmonary circulation2022

A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism.

Margaret R MacLean, Divya Pandya, Emilia M Swietlik, Nina Denver, Kirsty Mair, Nicholas W Morrell, Stefan Gräf, National Cohort Study for Idiopathic and Heritable Pulmonary Arterial Hypertension Consortium

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Margaret R MacLeanInstitute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK.ORCID 0000-0001-8214-7759
Divya PandyaDepartment of Medicine University of Cambridge Cambridge UK.
Emilia M SwietlikDepartment of Medicine University of Cambridge Cambridge UK.
Nina DenverInstitute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK.
Kirsty MairInstitute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK.
Nicholas W MorrellDepartment of Medicine University of Cambridge Cambridge UK.
Stefan GräfDepartment of Medicine University of Cambridge Cambridge UK.
National Cohort Study for Idiopathic and Heritable Pulmonary Arterial Hypertension Consortium
University of Cambridge · GBUniversity of Strathclyde · GB

Funding

British Heart Foundation CH/09/001/25945British Heart Foundation RG/08/006/25302British Heart Foundation RG/13/4/30107British Heart Foundation RG/16/2/32153British Heart Foundation RG/F/21/110047British Heart Foundation SP/12/12/29836British Heart Foundation SP/18/10/33975Medical Research Council MR/K020919/1Medical Research Council MR/T015713/1
6 · The paper itself

Abstract

The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1-pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body-weight in mice and man may be associated with increased estrogen metabolism.

Indexed as

estrogenestrogen metabolitesobesitypulmonary hypertensionsex

Identifiers

PMID36186719
PMCPMC9510900
OpenAlexW4296194230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.