Evidence map›Paper›PMID 36186424›Full record

ArticleFrontiers in genetics2022

Investigating CRISPR spacer targets and their impact on genomic diversification of

Alejandro R Walker, Robert C Shields

Abstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alejandro R WalkerDepartment of Oral Biology, University of Florida, Gainesville, FL, United States.
Robert C ShieldsDepartment of Biological Sciences, Arkansas State University, Jonesboro, AR, United States.

Funding

Exploring Integrative Conjugative Elements in the Biology and Ecology of Oral StreptococciR03DE029882 · NIDCR · ARKANSAS STATE UNIVERSITY · PI SHIELDS, ROBERT COLQUHOUN · 2021 to 2022
$270k
NIDCR NIH HHS R03 DE029882
6 · The paper itself

Abstract

CRISPR-Cas is a bacterial immune system that restricts the acquisition of mobile DNA elements. These systems provide immunity against foreign DNA by encoding CRISPR spacers that help target DNA if it re-enters the cell. In this way, CRISPR spacers are a type of molecular tape recorder of foreign DNA encountered by the host microorganism. Here, we extracted ∼8,000 CRISPR spacers from a collection of over three hundred

Indexed as

CRISPRCRISPR-Cashorizontal gene transferintegrative and conjugative elementpangenomeStreptococcus mutans

Identifiers

PMID36186424
PMCPMC9522601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.