Evidence map›Paper›PMID 36186242›Full record

ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2022

A Critical Assessment of Extemporaneous Formulations for Proton Pump Inhibitors: The Importance of Proper Vehicle Selection.

Ognjenka Rahić, Jasmina Hadžiabdić, Amina Tucak, Merima Sirbubalo, Lamija Hindija, Alisa Elezović, Edina Vranić

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Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ognjenka RahićFaculty of Pharmacy, Department of Pharmaceutical Technology (OR, JH, AT, MS, LH, AE, EV), University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Jasmina HadžiabdićFaculty of Pharmacy, Department of Pharmaceutical Technology (OR, JH, AT, MS, LH, AE, EV), University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Amina TucakFaculty of Pharmacy, Department of Pharmaceutical Technology (OR, JH, AT, MS, LH, AE, EV), University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Merima SirbubaloFaculty of Pharmacy, Department of Pharmaceutical Technology (OR, JH, AT, MS, LH, AE, EV), University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Lamija HindijaFaculty of Pharmacy, Department of Pharmaceutical Technology (OR, JH, AT, MS, LH, AE, EV), University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Alisa ElezovićFaculty of Pharmacy, Department of Pharmaceutical Technology (OR, JH, AT, MS, LH, AE, EV), University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Edina VranićFaculty of Pharmacy, Department of Pharmaceutical Technology (OR, JH, AT, MS, LH, AE, EV), University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the influence of vehicles on the stability of extemporaneous suspensions of proton pump inhibitors (PPIs), to single out the formulation most suitable for children, providing appropriate evidence and arguments.

methodsA review was performed of data identified from Medline, Embase, Science Direct, as well as public digital archive PubMed, including reference texts, related to the field of stability testing of extemporaneous PPI suspensions.

resultsFourteen selected formulations of extemporaneous suspensions are presented and discussed. Depending on the vehicle and its composition, which was analyzed and explained in detail, the suspensions had various beyond-use dates (BUDs).

conclusionsSelected vehicles and the process of preparation had great influence on the stability of extemporaneous PPI suspensions. The suspension with the longest BUD has been singled out, which is especially suitable for use in newborns. Because an explanation is provided for the influence of individual vehicle components on the stability of the mentioned suspensions, this can aid not only in the selection of an adequate formulation, but also in the development of new ones, which will be suited to individual patients.

Indexed as

extemporaneous suspensionsproton pump inhibitorsstabilityvehicle

Identifiers

PMID36186242
PMCPMC9514760

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.