Evidence map›Paper›PMID 36186172›Full record

ArticleWorld journal of clinical cases2022

Concurrent severe hepatotoxicity and agranulocytosis induced by

You-Lin Shao, Chun-Ming Ma, Jian-Ming Wu, Feng-Cai Guo, Suo-Cai Zhang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of clinical cases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

You-Lin ShaoDepartment of Hepatology, Changzhou Third People's Hospital, Changzhou 213001, Jiangsu Province, China. syl84289@aliyun.com.
Chun-Ming MaDepartment of Hepatology, Changzhou Third People's Hospital, Changzhou 213001, Jiangsu Province, China.
Jian-Ming WuDepartment of Hepatology, Changzhou Third People's Hospital, Changzhou 213001, Jiangsu Province, China.
Feng-Cai GuoDepartment of Hepatology, Changzhou Third People's Hospital, Changzhou 213001, Jiangsu Province, China.
Suo-Cai ZhangDepartment of Hepatology, Changzhou Third People's Hospital, Changzhou 213001, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVarious types of drug-induced liver injury are induced by CASE SUMMARY: A 65-year-old woman reported with severe hepatotoxicity and agranulocytosis 17 d after ingestion of PM. The results of the Roussel Uclaf Causality Assessment Method demonstrated a highly probable relationship between hepatotoxicity and PM, with a total score of 10. The Naranjo algorithm results indicated that agranulocytosis had a probable relationship with PM, with an overall score of 6. Granulocyte colony-stimulating factor (for once), a steroid, compound glycyrrhizin, and polyene phosphatidylcholine therapy were initiated. After 15 d of treatment, there was a gradual improvement in liver biochemistry, leukocytes, and neutrophils levels.

conclusionConcurrent hepatotoxicity and agranulocytosis are rare and critical adverse drug reactions of PM, which should be highly valued.

Indexed as

AgranulocytosisCase reportHepatotoxicityPolygonum multiflorum

Identifiers

PMID36186172
PMCPMC9516908

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.