Evidence map›Paper›PMID 36186093›Full record

ArticleJournal of pharmacopuncture2022

Neuroprotective Effect of Root Extracts of

Elham Shahriari Rad, Akram Eidi, Dariush Minai-Tehrani, Shahin Bonakdar, Shahram Shoeibi

Abstract read
In one paragraph

Article in Journal of pharmacopuncture, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elham Shahriari RadDepartment of Biology, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran.ORCID https://orcid.org/0000-0002-6710-407X
Akram EidiDepartment of Biology, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran.ORCID https://orcid.org/0000-0002-6673-5347
Dariush Minai-TehraniBioresearch Lab, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran.ORCID https://orcid.org/0000-0003-3589-7324
Shahin BonakdarNational Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.ORCID https://orcid.org/0000-0001-8759-3790
Shahram ShoeibiFood and Drug Laboratory Research Center (FDLRC), Iran Food and Drug Administration (IFDA), Ministry of Health and Medical Education, Tehran, Iran.ORCID https://orcid.org/0000-0002-5685-1213

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Oxidative stress plays a key role in chronic and acute brain disorders and neuronal damage associated with Alzheimer disease (AD) and other neurodegeneration symptoms. The neuroprotective effects of berberine and Methods: The methanolic extraction of barberry root was performed using a maceration procedure. Oxidative stress was induced in SH-SY5Y cells by H Results: The SH-SY5Y cell viability increased in both groups exposed to 75 and 150 ppm barberry extract compared with that in the H Conclusion: The outcomes of this study suggest that treatment of SH-SY5Y cells with barberry extract and berberine could suppress apoptosis by regulating the actions of Bcl-2 family members.

Indexed as

alzheimer diseaseapoptosisbarberryberberineoxidative stresssh-sy5y cells

Identifiers

PMID36186093
PMCPMC9510142

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.