ArticleFrontiers in systems neuroscience2022
The otolith vermis: A systems neuroscience theory of the Nodulus and Uvula.
Article in Frontiers in systems neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Visual motion does not bias gravity-referenced vestibular coding in the primate cerebellar nodulus and uvula.PLoS biology · 2026Article
- Gravity-Dependent Modulation of Downbeat Nystagmus: Insights From Velocity-Storage Dysfunction.Annals of clinical and translational neurology · 2026Article
- Ground-truth encoding of self-motion in the primate cerebellar nodulus and uvula.Nature communications · 2026Article
- A Multi-parametric MRI and Machine Learning Study of Cerebellar Structure in Youth with Neurofibromatosis Type 1.Cerebellum (London, England) · 2026Article
- Cortical vestibular-visual interactions and cross-modal plasticity-adaptive neural processes for stable perception.Frontiers in neural circuits · 2026Review
- Sensorimotor Transformations for Postural Control in the Vermis of the Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Validating sensory conflict theory and mitigating motion sickness in humans with galvanic vestibular stimulation.Communications engineering · 2025Article
- Convergence of vestibular and proprioceptive signals in the cerebellar nodulus/uvula enhances the encoding of self-motion in primates.Current biology : CB · 2025Article
- Skull vibration induced nystagmus, velocity storage and self-stability.Frontiers in neurology · 2025Article
- Human perception of self-motion and orientation during galvanic vestibular stimulation and physical motion.PLoS computational biology · 2024Article
- Cerebellar Metabolic Connectivity during Treadmill Walking before and after Unilateral Dopamine Depletion in Rats.International journal of molecular sciences · 2024Article
- A computational model of motion sickness dynamics during passive self-motion in the dark.Experimental brain research · 2024Article
- Internal models of self-motion: neural computations by the vestibular cerebellum.Trends in neurosciences · 2023Review
- A computational model of motion sickness dynamics during passive self-motion in the dark.Experimental brain research · 2023Article
- Video head impulse testing in patients with isolated (hemi)nodular infarction.Frontiers in neurology · 2023Article
- Modeling the effect of gravity on periodic alternating nystagmus.Journal of the neurological sciences · 2022Article
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Abstract
The Nodulus and Uvula (NU) (lobules X and IX of the cerebellar vermis) form a prominent center of vestibular information processing. Over decades, fundamental and clinical research on the NU has uncovered many aspects of its function. Those include the resolution of a sensory ambiguity inherent to inertial sensors in the inner ear, the otolith organs; the use of gravity signals to sense head rotations; and the differential processing of self-generated and externally imposed head motion. Here, I review these works in the context of a theoretical framework of information processing called the internal model hypothesis. I propose that the NU implements a forward internal model to predict the activation of the otoliths, and outputs sensory predictions errors to correct internal estimates of self-motion or to drive learning. I show that a Kalman filter based on this framework accounts for various functions of the NU, neurophysiological findings, as well as the clinical consequences of NU lesions. This highlights the role of the NU in processing information from the otoliths and supports its denomination as the "otolith" vermis.
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