ArticleWorld journal of hepatology2022
Alcohol intake is associated with a decreased risk of developing primary biliary cholangitis.
Article in World journal of hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Alcohol Consumption and Autoimmune Diseases.International journal of molecular sciences · 2025Review
- Causal association of inflammatory bowel disease with sarcoidosis and the mediating role of primary biliary cholangitis.Frontiers in immunology · 2024Article
- The treatment of primary biliary cholangitis: from shadow to light.Therapeutic advances in gastroenterology · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
backgroundPrimary biliary cholangitis (PBC) is a chronic progressive liver disease of unknown aetiology characterised by immune-mediated destruction of small and medium-sized intrahepatic bile ducts. There are few well-established risk factors and epidemiological studies are needed to further evaluate the pathogenesis of the disease.
aimTo evaluate the relationship between alcohol intake, smoking and marijuana use with PBC development.
methodsWe conducted a prevalent case control study of 200 cases and 200 age (within a five year age band) and sex-matched controls, identified from the Victorian PBC prevalence study. We assessed lifetime alcohol intake and smoking behaviour (both tobacco and marijuana) prior to PBC onset and used conditional logistic regression for analyses.
resultsAlcohol intake consistently showed a dose-dependent inverse association with case status, and this was most substantial for 21-30 years and 31-40 years (
conclusionAlcohol appears to have an inverse relationship with PBC. Smoking has been confirmed as an environmental risk factor for PBC. There was no association between marijuana use and PBC.
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