Evidence map›Paper›PMID 36185630›Full record

ArticleWorld journal of gastroenterology2022

Impact of sarcopenia on tumor response and survival outcomes in patients with hepatocellular carcinoma treated by trans-arterial (chemo)-embolization.

Gael Roth, Yann Teyssier, Maxime Benhamou, Mélodie Abousalihac, Stefano Caruso, Christian Sengel, Olivier Seror, Julien Ghelfi, Arnaud Seigneurin, Nathalie Ganne-Carrie and 5 more

Abstract read
In one paragraph

Article in World journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Albumin-bilirubin grade and sarcopenia as predictors of prognosis in patients with unresectable intermediate and advanced-stage hepatocellular carcinoma.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gael RothUniv. Grenoble-Alpes, Grenoble 38058, France.
Yann TeyssierUniv. Grenoble-Alpes, Grenoble 38058, France.
Maxime BenhamouDepartment of Radiology, CHU Avicenne-APHP, Bobigny 93000, France.
Mélodie AbousalihacDepartment of Hepatology, Gastroenterology and Digestive Oncology, CHU Grenoble Alpes, Grenoble 38043, France.
Stefano CarusoFunctional Genomics of Solid Tumors Laboratory, Centre de Recherche des Cordeliers-INSERM UMR 1138, Inserm, Université Paris, Paris 75006, France.
Christian SengelDepartment of Radiology, CHU Grenoble Alpes, Grenoble 38043, France.
Olivier SerorDepartment of Radiology, CHU Avicenne-APHP, Bobigny 93000, France.
Julien GhelfiUniv. Grenoble-Alpes, Grenoble 38058, France.
Arnaud SeigneurinUniv. Grenoble-Alpes, Grenoble 38058, France.
Nathalie Ganne-CarrieFunctional Genomics of Solid Tumors Laboratory, Centre de Recherche des Cordeliers-INSERM UMR 1138, Inserm, Université Paris, Paris 75006, France.
Elia GiganteDepartment of Hepatology, CHU Avicenne-APHP, Bobigny 93000, France.
Lorraine BlaiseDepartment of Hepatology, CHU Avicenne-APHP, Bobigny 93000, France.
Olivier SutterDepartment of Radiology, CHU Avicenne-APHP, Bobigny 93000, France.
Thomas DecaensUniv. Grenoble-Alpes, Grenoble 38058, France.
Jean-Charles NaultFunctional Genomics of Solid Tumors Laboratory, Centre de Recherche des Cordeliers-INSERM UMR 1138, Inserm, Université Paris, Paris 75006, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAt the diagnosis of hepatocellular carcinoma (HCC), more than 90% of HCC patients present cirrhosis, a clinical condition often associated to malnutrition. Sarcopenia is an indirect marker of malnutrition assessable on computed tomography (CT).

aimTo evaluate the prognostic value of sarcopenia in patients with HCC treated by trans-arterial (chemo)-embolization.

methodsPatients with HCC treated by a first session of trans-arterial (chemo)embolization and an available CT scan before treatment were included. Sarcopenia was assessed using skeletal muscle index at baseline and at the first radiological assessment. Radiological response was recorded after the first session of treatment using mRECIST.

resultsOf 225 patients treated by trans-arterial bland embolization (

conclusionSarcopenia is associated with tumor progression and poor survival outcomes after trans-arterial (chemo)-embolization for HCC.

Indexed as

Carcinoma, HepatocellularChemoembolization, TherapeuticLiver NeoplasmsMalnutritionSarcopeniaHumansRetrospective StudiesBland embolizationHepatocellular carcinomaSarcopeniaSkeletal muscle indexTransarterial chemoembolization

Identifiers

PMID36185630
PMCPMC9521519

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.