Evidence map›Paper›PMID 36185610›Full record

ArticleTheranostics2022

Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression.

Si Chen, Xiang Li, Yinghua Li, Xing Yuan, Chenchen Geng, Songyan Gao, Jinyang Li, Bohan Ma, Zhe Wang, Wuyuan Lu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Si ChenSchool of Medicine or Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
Xiang LiSchool of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Yinghua LiSchool of Medicine or Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
Xing YuanSchool of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Chenchen GengSchool of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Songyan GaoSchool of Medicine or Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
Jinyang LiKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200030, China.
Bohan MaThe First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710049, China.
Zhe WangInstitute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
Wuyuan LuKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200030, China.
Hong-Gang HuSchool of Medicine or Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
Shanghai University · CNSecond Military Medical University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsNeoplasmsCell Cycle ProteinsHumansPeptidesProto-Oncogene Proteins c-mdm2Tumor Suppressor Protein p53Antineoplastic AgentsCell Cycle ProteinsMDM2 protein, humanPeptidesProto-Oncogene Proteins c-mdm2Tumor Suppressor Protein p53anticancerMDM2/MDMXp53PROTACstapled peptide

Identifiers

PMID36185610
PMCPMC9516243
OpenAlexW4300690266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.