Evidence map›Paper›PMID 36185452›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Human fetal skin derived merkel cells display distinctive characteristics

Katarzyna Michalak-Micka, Dominic Rütsche, Luca Mazzone, Vanessa L Büchler, Ueli Moehrlen, Agnes S Klar, Thomas Biedermann

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katarzyna Michalak-MickaTissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Zurich, Switzerland.
Dominic RütscheTissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Zurich, Switzerland.
Luca MazzoneChildren's Research Center (CRC), University Children's Hospital Zurich, Zurich, Switzerland.
Vanessa L BüchlerTissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Zurich, Switzerland.
Ueli MoehrlenChildren's Research Center (CRC), University Children's Hospital Zurich, Zurich, Switzerland.
Agnes S KlarTissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Zurich, Switzerland.
Thomas BiedermannTissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human skin contains specialized neuroendocrine Merkel cells responsible for fine touch sensation. In the present study, we performed in-depth analysis of Merkel cells in human fetal back skin. We revealed that these Merkel cells expressed cytokeratin 20 (CK20), were positive for the neuroendocrine markers synaptophysin and chromogranin A, and the mechanosensitive ion channel Piezo2. Further, we demonstrated that Merkel cells were present in freshly isolated human fetal epidermal cells

Indexed as

CK20human fetal skinMerkel cellskin substituteskin tissue engineering

Identifiers

PMID36185452
PMCPMC9520781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.