Evidence map›Paper›PMID 36185357›Full record

ArticleiScience2022

Crowding and confinement act in concert to slow DNA diffusion within cell-sized droplets.

Mehdi Shafiei Aporvari, Steven Dang, Juexin Marfai, Kara Coursey, Ryan McGorty, Rae M Robertson-Anderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Bending Dynamics of Magnetic Filaments at a Curved Bacterial Bath Interface.Langmuir : the ACS journal of surfaces and colloids · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mehdi Shafiei AporvariDepartment of Physics and Biophysics, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USA.
Steven DangDepartment of Physics and Biophysics, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USA.
Juexin MarfaiDepartment of Physics and Biophysics, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USA.
Kara CourseyDepartment of Physics and Biophysics, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USA.
Ryan McGortyDepartment of Physics and Biophysics, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USA.
Rae M Robertson-AndersonDepartment of Physics and Biophysics, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dynamics of biological macromolecules, such as DNA, in crowded and confined environments are critical to understanding cellular processes such as transcription, infection, and replication. However, the combined effects of cellular confinement and crowding on macromolecular dynamics remain poorly understood. Here, we use differential dynamic microscopy to investigate the diffusion of large DNA molecules confined in cell-sized droplets and crowded by dextran polymers. We show that confined and crowded DNA molecules exhibit universal anomalous subdiffusion with scaling that is insensitive to the degree of confinement and crowding. However, effective DNA diffusion coefficients

Indexed as

BiochemistryBiomoleculesCondensed matter physics

Identifiers

PMID36185357
PMCPMC9523355

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.