Silica Inverse Opal Nanostructured Sensors for Enhanced Immunodetection of Extracellular Vesicles by Quartz Crystal Microbalance with Dissipation Monitoring.

Jugal Suthar, Alberto Alvarez-Fernandez, Alaric Taylor, Maximiliano J Fornerod, Gareth R Williams, Stefan Guldin

Abstract read

In one paragraph

Article in ACS applied nano materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Oxide and Hydrogel Inverse Opals and Their Applications as Physical, Chemical and Biological Sensors.Sensors (Basel, Switzerland) · 2025
Review
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.Nanoscale horizons · 2023
Article
Recent developments in biosensing methods for extracellular vesicle protein characterization.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2023
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jugal SutharDepartment of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.

Alberto Alvarez-FernandezDepartment of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.ORCID https://orcid.org/0000-0002-2607-3035

Alaric TaylorDepartment of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.ORCID https://orcid.org/0000-0001-6494-8309

Maximiliano J FornerodDepartment of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.ORCID https://orcid.org/0000-0001-6858-299X

Gareth R WilliamsUCL School of Pharmacy, University College London, Bloomsbury, 29-39 Brunswick Square, London WC1N 1AX, U.K.ORCID https://orcid.org/0000-0002-3066-2860

Stefan GuldinDepartment of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.ORCID https://orcid.org/0000-0002-4413-5527

Funding

Medical Research Council MR/R000328/1

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are nanosized circulating assemblies that contain biomarkers considered promising for early diagnosis within neurology, cardiology, and oncology. Recently, acoustic wave biosensors, in particular based on quartz crystal microbalance with dissipation monitoring (QCM-D), have emerged as a sensitive, label-free, and selective EV characterization platform. A rational approach to further improving sensing detection limits relies on the nanostructuration of the sensor surfaces. To this end, inorganic inverse opals (IOs) derived from colloidal self-assembly present a highly tunable and scalable nanoarchitecture of suitable feature sizes and surface chemistry. This work systematically investigates their use in two-dimensional (2D) and three-dimensional (3D) for enhanced QCM-D EV detection. Precise tuning of the architecture parameters delivered improvements in detection performance to sensitivities as low as 6.24 × 10

Identifiers

PMID36185167

DOI10.1021/acsanm.2c02775

PMCPMC9513796

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.