ArticleWorld journal of clinical pediatrics2022
Childhood constipation: Current status, challenges, and future perspectives.
Article in World journal of clinical pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Osmotic and stimulant laxatives for the management of childhood constipation.The Cochrane database of systematic reviews · 2026Pooled it
- Efficacy of physiotherapeutic interventions in the management of functional constipation in pediatric and adolescent populations: a systematic review and meta-analysis.European journal of pediatrics · 2026Pooled it
- Systematic review of fruit and vegetable voucher interventions for pregnant women and families with young children.Public health nutrition · 2025Pooled it
- A post hoc analysis of linaclotide in pediatric patients with functional constipation and neurodevelopmental disorders.Journal of pediatric gastroenterology and nutrition · 2026Trial
- High-resolution anorectal manometry in children with constipation-associated fecal incontinence.European journal of pediatrics · 2026Article
- Retrospective Analysis of Point-of-Care Ultrasound Results in the Follow-Up of Paediatric Functional Constipation.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- The relationship between constipation and stress among medical students in Saudi Arabia: A self-reported study.Journal of family medicine and primary care · 2026Article
- Gastrodin alleviates loperamide-induced slow transit constipation in mice by modulating the MAPK signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Usefulness of ultrasound in diagnosing constipation in children: a narrative review.Frontiers in pediatrics · 2026Review
- Quality of life among Indian paediatric patients suffering from constipation: An evaluative study.Bioinformation · 2026Article
- The impact of pediatric constipation on appendicitis: a prospective birth cohort in the Japan Environment and Children's Study.BMC pediatrics · 2025Article
- Breaking the cycle: Psychological and social dimensions of pediatric functional gastrointestinal disorders.World journal of clinical pediatrics · 2025Article
- Hospitalization Trends and Healthcare Resource Utilization for Fecal Impactions in Pediatric Patients with Functional Constipation.Journal of clinical medicine · 2025Article
- Emergency Laparotomy for Abdominal Compartment Syndrome in a Child due to Chronic Functional Constipation.Case reports in pediatrics · 2025Article
- The Association of Short-Chain Fatty Acids with the Occurrence of Gastrointestinal Symptoms in Infants.International journal of molecular sciences · 2024Article
- Exploring Diagnostic Priorities: The Role of Colonic Manometry in Evaluating Pediatric Patients with Intractable Idiopathic Constipation Prior to Sacral Nerve Stimulation.Children (Basel, Switzerland) · 2024Article
- Facilitators and barriers of adherence to rectal interventions by parents of young children with functional constipation: a qualitative study.Frontiers in pediatrics · 2024Article
- Review
- Article
- Dietary Fibers in Healthy Children and in Pediatric Gastrointestinal Disorders: A Practical Guide.Nutrients · 2023Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Constipation in children is a major health issue around the world, with a global prevalence of 9.5%. They present to clinicians with a myriad of clinical signs. The Rome IV symptom-based criteria are used to diagnose functional constipation. Functional constipation is also a huge financial burden for healthcare system and has a detrimental impact on health-related quality of life of children. There are various risk factors identified globally, including centrally connected factors such as child abuse, emotional and behavioral issues, and psychological stress. Constipation is also precipitated by a low-fiber diet, physical inactivity, and an altered intestinal microbiome. The main pathophysiological mechanism is stool withholding, while altered rectal function, anal sphincter, pelvic floor, and colonic dysfunction also play important roles. Clinical evaluation is critical in making a diagnosis, and most investigations are only required in refractory patients. In the treatment of childhood constipation, both nonpharmacological (education and de-mystification, dietary changes, toilet training, behavioral interventions, biofeedback, and pelvic floor physiotherapy), and pharmacological (osmotic and stimulant laxatives and novel drugs like prucalopride and lubiprostone) interventions are used. For children with refractory constipation, transanal irrigation, botulinum toxin, neuromodulation, and surgical treatments are reserved. While frequent use of probiotics is still in the experimental stage, healthy dietary habits, living a healthy lifestyle and limiting exposure to stressful events, are all beneficial preventive measures.
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