ArticleTherapeutic advances in musculoskeletal disease2022
Association between bone trace elements and osteoporosis in older adults: a cross-sectional study.
Article in Therapeutic advances in musculoskeletal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dietary Copper Intake and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies.Calcified tissue international · 2025Pooled it
- Perioperative Management of Patients Undergoing Periacetabular Osteotomy: An Evidence-Based Review.Current reviews in musculoskeletal medicine · 2026Review
- Research Progress of Cuproptosis in Orthopaedics: Opportunities and Challenges.Journal of cellular and molecular medicine · 2026Review
- Serum iron levels as a risk factor for Osteoporosis-Related pathological fractures.Aging clinical and experimental research · 2025Article
- Article
- The association between dietary mineral intake and bone mineral density: a cross-sectional study.Journal of health, population, and nutrition · 2025Article
- Associations between multiple metals exposure and bone mineral density: a population-based study in U.S. children and adolescents.BMC musculoskeletal disorders · 2025Article
- Article
- Analysis of the association between mixed exposure to multiple metals and comorbidity of osteopenia or osteoporosis: baseline data from the Chinese Multi-Ethnic Cohort study (CMEC).BMC public health · 2025Article
- The Role of Copper Intake in Bone Health: A Quantitative Analysis in Postmenopausal Spanish Women.European journal of investigation in health, psychology and education · 2025Article
- Bones or Stones: How Can We Apply Geophysical Techniques in Bone Research?International journal of molecular sciences · 2024Article
- Hair and Serum Trace Element and Mineral Levels Profiles in Women with Premenopausal and Postmenopausal Osteoporosis.Biological trace element research · 2024Article
- The study findings demonstrated a significant association between C-reactive protein levels and trabecular bone score : NHANES 2005-2008.Journal of orthopaedic surgery and research · 2024Article
- The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.Journal of clinical medicine · 2024Review
- Mechanical Properties and Corrosion Rate of ZnAg3 as a Novel Bioabsorbable Material for Osteosynthesis.Journal of functional biomaterials · 2024Article
- Nutrition-Based Support for Osteoporosis in Postmenopausal Women: A Review of Recent Evidence.International journal of women's health · 2024Review
- Prevalence and risk factors of osteopenia in adults with short bowel syndrome: a retrospective longitudinal cohort study.Frontiers in medicine · 2024Article
- Article
- Association between inflammatory bowel disease and osteoporosis in European and East Asian populations: exploring causality, mediation by nutritional status, and shared genetic architecture.Frontiers in immunology · 2024Article
- Novel insights into the role of metabolic disorder in osteoarthritis.Frontiers in endocrinology · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Metal micronutrients deficiency may be one of the risk factors for the development of osteoporosis. This study aimed to measure the trace element contents in human bone tissue to analyze the relationship between micronutrients and osteoporosis. Design: A cross-sectional survey was performed on data from 51 elderly patients with proximal femoral fracture. Methods: The concentrations of calcium, phosphorus, manganese, iron, copper, and zinc in bone tissue samples from 51 elderly patients with proximal femoral fracture were determined by energy-dispersive X-ray fluorescence (EDX). Subjects were divided into osteoporosis and non-osteoporosis groups according to their bone mineral density (BMD) Results: There was no statistical difference in age, sex, body mass index (BMI), serum albumin, biochemical blood indices, and bone turnover markers between the two groups. The Mann-Whitney Conclusion: Manganese, copper, and zinc play an essential role in bone mineralization and metabolism. Among them, zinc may be most closely related to osteoporosis and play a key role in bone development and maintenance of bone mass. Therefore, we believe that the design of zinc-rich compounds or nutrients as a new complementary factor to increase the intake of zinc for the elderly could be able to prevent and intervene in the occurrence of osteoporosis in the early stage.
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