Evidence map›Paper›PMID 36184675›Full record

Observational studyWorld journal of surgery2022

Quality of Life in Post-Surgical Hypoparathyroidism (PoSH) in Thyroid and Parathyroid Surgery.

Sarah L Hillary, Je Ern Chooi, Jonathan Wadsley, John D Newell-Price, Nicola J Brown, Saba P Balasubramanian

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07416149 (Reducing Post-operative Hypoparathyroidism With Probe-based Near Infrared Autofluorescence), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07416149 narecruitingnot on this mapstarted 2025, after this paper: background citation

Reducing Post-operative Hypoparathyroidism With Probe-based Near Infrared Autofluorescence (NIRAF)- Assisted Total Thyroidectomy Versus Conventional Total Thyroidectomy, a Randomized-controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2025 to 2028Enrolled210ConditionsHypocalcemia, Parathyroid, Hypoparathyroidism Post-surgical, Total ThyroidectomyArmsPTeye™ parathyroid detection system
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  9. Review
  10. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarah L HillaryDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK. sarah.hillary@doctors.org.uk.ORCID 0000-0002-6938-6920
Je Ern ChooiDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Jonathan WadsleyDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
John D Newell-PriceDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Nicola J BrownDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Saba P BalasubramanianDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-surgical hypoparathyroidism (PoSH) is often long term, with significant associated morbidity and ongoing treatment. A recent systematic review found impaired quality of life (QoL) in patients with PoSH, despite stable treatment. Most studies did not include an appropriate control arm and further studies were recommended, taking into account underlying disease and comorbidities. This study aims to compare QoL in patients with PoSH with appropriate control groups.

methodsThis was a cross-sectional observational study using the general quality of life SF-36 tool and a hypocalcaemia symptom score (HcSS) to assess QoL in patients with PoSH and controls (who had similar surgery but without PoSH). Participants were identified from two patient groups (the Butterfly Thyroid Cancer Trust and the Association for Multiple Endocrine Neoplasia Disorders) and a single tertiary centre in the UK.

resultsFour hundred and thirty-nine responses (female n = 379, PoSH n = 89) were included with a median (range) age of 52 (19-92) years. Reported dates of surgery ranged from 1973 to 2019. HcSS scores showed significantly more associated symptoms in patients with PoSH than those without (p < 0.001). Although there was no overall difference in QoL between groups, patients with PoSH consistently had lower scores (p = 0.008) in the energy/fatigue subdomain of the SF-36.

conclusionPatients with PoSH reported significantly more fatigue and loss of energy compared to appropriately matched controls, but overall QoL was not significantly different. Standardised QoL measures may not be sensitive enough to highlight the impact on QoL in these patients. A disease-specific tool may be required.

Indexed as

HypocalcemiaHypoparathyroidismAgedAged, 80 and overCross-Sectional StudiesFatigueFemaleHumansMaleMiddle AgedQuality of LifeThyroid Gland

Identifiers

PMID36184675
PMCPMC9636109

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.