Evidence map›Paper›PMID 36184638›Full record

ArticleEnvironmental health : a global access science source2022

Does early life exposure to exogenous sources of reactive oxygen species (ROS) increase the risk of respiratory and allergic diseases in children? A longitudinal cohort study.

Teresa To, Emilie Terebessy, Jingqin Zhu, Kimball Zhang, Pascale Sj Lakey, Manabu Shiraiwa, Marianne Hatzopoulou, Laura Minet, Scott Weichenthal, Sharon Dell and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health : a global access science source, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Teresa ToDalla Lana School of Public Health, University of Toronto, Toronto, Canada. teresa.to@sickkids.ca.
Emilie TerebessyChild Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada.
Jingqin ZhuChild Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada.
Kimball ZhangChild Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada.
Pascale Sj LakeyDepartment of Chemistry, University of California Irvine, Irvine, USA.
Manabu ShiraiwaDepartment of Chemistry, University of California Irvine, Irvine, USA.
Marianne HatzopoulouDepartment of Civil and Mineral Engineering, University of Toronto, Toronto, Canada.
Laura MinetDepartment of Civil Engineering, University of Victoria, Victoria, Canada.
Scott WeichenthalDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.
Sharon DellDepartment of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Dave StiebEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, Canada.
SickKids Foundation · CAUniversity of California, Irvine · USUniversity of Toronto · CAHealth Canada · CAHospital for Sick Children · CAMcGill University · CAProvincial Health Services Authority · CAUniversity of Victoria · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundExcess reactive oxygen species (ROS) can cause oxidative stress damaging cells and tissues, leading to adverse health effects in the respiratory tract. Yet, few human epidemiological studies have quantified the adverse effect of early life exposure to ROS on child health. Thus, this study aimed to examine the association of levels of ROS exposure at birth and the subsequent risk of developing common respiratory and allergic diseases in children.

methods1,284 Toronto Child Health Evaluation Questionnaire (T-CHEQ) participants were followed from birth (born between 1996 and 2000) until outcome, March 31, 2016 or loss-to-follow-up. Using ROS data from air monitoring campaigns and land use data in Toronto, ROS concentrations generated in the human respiratory tract in response to inhaled pollutants were estimated using a kinetic multi-layer model. These ROS values were assigned to participants' postal codes at birth. Cox proportional hazards regression models, adjusted for confounders, were then used to estimate hazard ratios (HR) with 95% confidence intervals (CI) per unit increase in interquartile range (IQR).

resultsAfter adjusting for confounders, iron (Fe) and copper (Cu) were not significantly associated with the risk of asthma, allergic rhinitis, nor eczema. However, ROS, a measure of the combined impacts of Fe and Cu in PM

conclusionThese findings showed that ROS exposure in early life significantly increased the childhood risk of asthma, but not allergic rhinitis and eczema.

Indexed as

Air PollutantsAsthmaEczemaEnvironmental PollutantsRhinitisRhinitis, AllergicChildCohort StudiesCopperHumansInfant, NewbornIronLongitudinal StudiesParticulate MatterReactive Oxygen SpeciesRespiratory SystemAir PollutantsCopperEnvironmental PollutantsIronParticulate MatterReactive Oxygen SpeciesAir pollutionAllergic rhinitisAsthmaEarly life exposuresEczemaReactive oxygen species

Identifiers

PMID36184638
PMCPMC9528154
OpenAlexW4300003575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.