Evidence map›Paper›PMID 36184393›Full record

ArticleUltrasound in medicine & biology2023

In Vivo Longitudinal Monitoring of Cardiac Remodeling in Murine Ischemia Models With Adaptive Bayesian Regularized Cardiac Strain Imaging: Validation Against Histology.

Rashid Al Mukaddim, Ashley M Weichmann, Rachel Taylor, Timothy A Hacker, Thomas Pier, Joseph Hardin, Melissa Graham, Elizabeth M Casper, Carol C Mitchell, Tomy Varghese

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Lagrangian deformation tracking for strain imaging.Progress in biomedical engineering (Bristol, England) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rashid Al MukaddimMedical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA. Electronic address: mukaddim@wisc.edu.
Ashley M WeichmannSmall Animal Imaging and Radiotherapy Facility, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Rachel TaylorCardiovascular Physiology Core Facility, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Timothy A HackerCardiovascular Physiology Core Facility, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Thomas PierExperimental Animal Pathology Lab, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Joseph HardinExperimental Animal Pathology Lab, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Melissa GrahamComparative Pathology Laboratory, Research Animal Resources and Compliance (RARC), University of Wisconsin-Madison, Madison, Wisconsin, USA.
Elizabeth M CasperUniversity of Wisconsin Hospitals and Clinics, UW Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Carol C MitchellMedicine/Division of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Tomy VargheseMedical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
University of Wisconsin–Madison · USUniversity of Wisconsin System · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Early Detection of Vascular Dysfunction Using Biomarkers from Lagrangian Carotid Strain ImagingR01HL147866 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2020 to 2023
$2.9M
Ultrasonic and Photoacoustic Imaging System for Cancer & Cardiovascular ResearchS10OD018505 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2015 to 2015
$908k
NCI NIH HHS P30 CA014520NHLBI NIH HHS R01 HL147866NIH HHS S10 OD018505
6 · The paper itself

Abstract

Adaptive Bayesian regularized cardiac strain imaging (ABR-CSI) uses raw radiofrequency signals to estimate myocardial wall contractility as a surrogate measure of relative tissue elasticity incorporating regularization in the Bayesian sense. We determined the feasibility of using ABR-CSI -derived strain for in vivo longitudinal monitoring of cardiac remodeling in a murine ischemic injury model (myocardial infarction [MI] and ischemia-reperfusion [IR]) and validated the findings against ground truth histology. We randomly stratified 30 BALB/CJ mice (17 females, 13 males, median age = 10 wk) into three surgical groups (MI = 10, IR = 12, sham = 8) and imaged pre-surgery (baseline) and 1, 2, 7 and 14 d post-surgery using a pre-clinical high-frequency ultrasound system (VisualSonics Vevo 2100). We then used ABR-CSI to estimate end-systolic and peak radial (e

Indexed as

CardiomyopathiesMyocardial InfarctionAnimalsBayes TheoremFemaleHeartMaleMiceMyocardiumVentricular RemodelingAdaptive BayesianCardiacInfarctionIschemia–reperfusionLongitudinal strainMyocardialRadial strainUltrasound

Identifiers

PMID36184393
PMCPMC9712162
OpenAlexW4297994941

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.