ArticlePain management nursing : official journal of the American Society of Pain Management Nurses2023
Pain Interference in End Stage Kidney Disease is Associated with Changes in Gut Microbiome Features Before and After Kidney Transplantation.
Article in Pain management nursing : official journal of the American Society of Pain Management Nurses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Pain Interference in Maintenance Hemodialysis: A Single-Center Cross-Sectional Study Using the Pain Effects Scale (PES).Journal of clinical medicine · 2026Article
- Role of microbiota in pain: From bench to bedside.iMetaOmics · 2025Review
- The Gut Microbiome and Symptom Burden After Kidney Transplantation: An Overview and Research Opportunities.Biological research for nursing · 2024Review
- Associations Between Gut Microbial Features and Sickness Symptoms in Kidney Transplant Recipients.Biological research for nursing · 2024Article
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundPain, a common debilitating symptom among kidney transplant recipients (KTRs), is among the most common and undertreated symptoms after kidney transplantation.
aimsCharacterize associations between gut microbiome features and pain interference before and after kidney transplantation.
designLongitudinal, repeated measures study, collecting fecal specimens and pain interference data pretransplant and 3 months posttransplant.
settingParticipants were recruited at the kidney transplant clinic at the University of Illinois Hospital & Health Sciences System. PARTICIPANTS/SUBJECTS: 19 living donor kidney transplant recipients.
methodsWe assessed fecal microbial community structure with shotgun metagenomic sequencing; we used pain interference scores derived from the Patient-Reported Outcomes Measurement Information System-57.
resultsWe measured a reduction in the Shannon diversity index in both groups after transplantation but observed no significant differences between groups at either time point. We did observe significant differences in fecal microbial Bray-Curtis similarity index among those reporting pain interference pre- transplant versus no pain interference at 3-months posttransplant (R = .306, p = .022), and between pain interference groups at posttransplant (R = .249, p = .041). Pairwise models showed significant differences between groups posttransplant in relative abundances of several taxa, including a 5-fold reduction.ßin Akkermansia among those with pain interference and a higher relative abundance of taxa associated with chronic inflammation in those with pain interference posttransplant. Functional gene analysis identified two features that were significantly enriched in those with pain interference, including a peptide transport system gene.
conclusionsGut microbiota community structure differs between groups with and without pain interference at 3 months after kidney transplantation. Several taxa involved in intestinal barrier integrity and chronic inflammation were associated with posttransplant pain.
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